Overview
Albendazole is a benzimidazole carbamate derivative widely used as an anthelmintic agent. It is effective against a variety of parasitic worms, including roundworms, tapeworms, and flukes. The drug works by inhibiting the polymerization of tubulin, disrupting the parasites' microtubule structure and leading to their death. Albendazole is commonly administered orally in tablet or suspension form. It is metabolized in the liver to its active form, albendazole sulfoxide, which is responsible for its therapeutic effects. The drug is listed on the World Health Organization's List of Essential Medicines, highlighting its importance in global health.
Physical and Chemical Properties
Albendazole is a white to off-white crystalline powder with a molecular weight of 265.33 g/mol. It has a melting point of 208-210°C and is practically insoluble in water. However, it dissolves well in organic solvents like dimethyl sulfoxide (DMSO) and methanol. The drug is stable under normal storage conditions but should be protected from light and moisture to prevent degradation. Its chemical stability makes it suitable for formulation into various dosage forms, including tablets, suspensions, and veterinary pastes.
Main Applications
Albendazole is primarily used to treat parasitic infections in both humans and animals. In humans, it is effective against neurocysticercosis, hydatid disease, and intestinal nematode infections like ascariasis and hookworm. In veterinary medicine, it is used to control parasitic infections in livestock, poultry, and pets. The drug is also employed in mass drug administration programs for parasitic disease control in endemic regions. Its broad-spectrum activity and relatively low cost make it a cornerstone of parasitic infection management in resource-limited settings.
Safety and Storage
Albendazole should be handled with care to avoid inhalation or direct skin contact. Appropriate personal protective equipment, such as gloves and masks, should be used during handling. The drug is contraindicated in pregnant women due to potential teratogenic effects. Storage should be in a cool, dry place, away from light and moisture. Bulk quantities should be kept in tightly sealed containers to maintain stability. Proper disposal methods should be followed to minimize environmental impact.
B2B Procurement Guide
When procuring albendazole in bulk, buyers should verify the CAS number (54965-21-8) and request certificates of analysis to confirm purity and quality. Pharmaceutical-grade albendazole should meet pharmacopeial standards such as USP or EP. Bulk purchases may require regulatory documentation, especially for international shipments. Buyers should also consider supplier reliability, lead times, and storage requirements. Prices vary based on purity and quantity, with discounts often available for large orders.