Overview
Ailanthone is a bioactive quassinoid compound derived from the bark and leaves of the tree-of-heaven (Ailanthus altissima). It has garnered attention for its potent biological activities, including insecticidal and antitumor effects. The compound is structurally classified as a degraded triterpene and is part of the quassinoid family, known for their diverse pharmacological properties. Initially studied for its role in plant defense mechanisms, ailanthone is now explored in agricultural and pharmaceutical industries. Its ability to disrupt insect growth and inhibit tumor cell proliferation makes it a compound of significant interest for research and commercial applications.
Physical and Chemical Properties
Ailanthone is a crystalline solid with a molecular weight of 376.4 g/mol and a melting point around 200-205°C. It is soluble in polar organic solvents such as methanol and ethanol but has limited solubility in water. This characteristic influences its formulation in agricultural and laboratory settings. The compound's stability under standard storage conditions (cool, dry, and protected from light) ensures its longevity in industrial use. Its molecular structure, featuring multiple oxygen-containing functional groups, contributes to its reactivity and biological efficacy.
Main Applications
In agriculture, ailanthone is primarily used as a natural insecticide and herbicide. Its mode of action involves disrupting metabolic pathways in pests and weeds, offering an eco-friendly alternative to synthetic chemicals. Research also highlights its potential in integrated pest management systems. The pharmaceutical industry investigates ailanthone for its antitumor properties, particularly in inhibiting cancer cell proliferation. Preliminary studies suggest it may interfere with cellular signaling pathways, though further clinical validation is required. Additionally, it serves as a reference compound in biochemical research.
Safety and Storage
Ailanthone requires careful handling due to its bioactive nature. Personal protective equipment (PPE), including gloves and goggles, is recommended to prevent skin contact or inhalation. Proper ventilation is essential during laboratory or industrial use. Storage should be in tightly sealed containers, away from moisture and direct sunlight, to maintain stability. Disposal must comply with local environmental regulations to minimize ecological impact. Safety data sheets (SDS) should be consulted for specific handling protocols.
B2B Procurement Guide
When procuring ailanthone, prioritize suppliers with certifications (e.g., ISO, GMP) to ensure quality and traceability. Key specifications to verify include purity (typically ≥95% for research-grade) and CAS number (981-15-7). Bulk purchases may qualify for discounts, but confirm scalability of production with the supplier. Consider logistical factors such as shipping conditions (temperature-controlled if necessary) and lead times. Request samples for preliminary testing to validate compatibility with intended applications.
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