Overview
Agathadiol Standard is a certified reference material (CRM) belonging to the kaurane diterpenoid class, originally isolated from Agathis australis (kauri tree) resin. As a high-purity analytical standard, it plays a vital role in method validation for chromatographic techniques like HPLC and GC-MS in pharmaceutical and botanical research. The compound's stereospecific structure (16β,17-diol configuration) makes it particularly valuable for studying diterpenoid metabolism and verifying the authenticity of plant-derived medicinal products. Regulatory laboratories commonly use it to establish calibration curves for quantitative analysis of related compounds in complex matrices.
Physical and Chemical Properties
This diterpenoid standard exhibits characteristic stability when stored properly, with a defined melting range of 198-202°C. Its molecular weight of 306.49 g/mol and lipophilic nature (logP ≈4.2) influence its chromatographic behavior, typically eluting in mid-polarity mobile phase systems. The crystalline form shows negligible hygroscopicity but should be protected from prolonged light exposure due to potential photo-degradation. Spectroscopic properties include distinct UV-Vis absorption maxima at 210 nm and characteristic IR bands for hydroxyl groups (3400 cm⁻¹) and tetracyclic skeleton vibrations.
Main Applications
In pharmaceutical quality control, Agathadiol Standard serves as a marker compound for kauri resin-containing formulations, ensuring batch-to-batch consistency. Research laboratories employ it to develop analytical methods for diterpenoid quantification in anti-inflammatory and antimicrobial herbal preparations. The standard also facilitates structural elucidation in natural product chemistry through NMR comparison studies. Some biotech applications utilize it as a starting material for semi-synthetic derivatives with modified biological activity profiles.
Safety and Storage
While not classified as acutely toxic, proper lab precautions including gloves and safety goggles are recommended due to potential respiratory irritation from powder aerosols. Spills should be contained with inert absorbents and disposed as organic waste. Long-term stability requires storage at -20°C in sealed amber vials with desiccant packs. For working solutions, ethanol or methanol stocks are stable for 3 months at 4°C when protected from light. Always verify purity by HPLC before critical analytical use after prolonged storage.
B2B Procurement Guide
Bulk purchasers should prioritize suppliers providing ISO 17034 accredited certificates of analysis (COA) with detailed chromatograms and residual solvent data. Minimum order quantities typically start at 1g for high-purity (≥98%) material, with volume discounts available at 10g+ purchases. Key procurement considerations include verifying batch-specific NMR data for stereochemical purity and requesting stability studies if the material will undergo international shipping. Some vendors offer customized solutions pre-prepared at common working concentrations (e.g., 1mg/mL in methanol) for immediate laboratory use.
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