Overview
Adenosylhomocysteine (SAH) is a nucleoside derivative formed during methylation reactions involving S-adenosylmethionine (SAM). It serves as a critical intermediate in biochemical pathways, particularly in methylation processes and nucleic acid synthesis. SAH is also known for its role as a feedback inhibitor of methyltransferases, making it a significant compound in cellular regulation. SAH is widely studied in biochemistry and molecular biology due to its involvement in epigenetic modifications and metabolic pathways. Researchers often use SAH to investigate enzyme mechanisms and to develop inhibitors for therapeutic applications. Its stability and solubility in water make it a practical compound for laboratory use.
Physical and Chemical Properties
Adenosylhomocysteine is a white to off-white crystalline powder with a molecular weight of 384.41 g/mol. It is hygroscopic and sensitive to light and moisture, requiring careful storage conditions. The compound decomposes at approximately 180-185°C and is soluble in water, making it suitable for aqueous solutions in laboratory settings. SAH's chemical structure includes an adenosine moiety linked to homocysteine, which contributes to its role in methylation reactions. Its solubility in water and slight solubility in ethanol allow for versatile use in biochemical assays. The compound's stability under proper storage conditions ensures reliable performance in research applications.
Main Applications
SAH is primarily used in biochemical research to study methylation processes and enzyme inhibition. It serves as a substrate or inhibitor in assays involving methyltransferases, providing insights into epigenetic regulation and metabolic pathways. The compound is also employed in pharmaceutical research to develop inhibitors for diseases related to methylation dysregulation. In addition to research, SAH is utilized in diagnostic applications to measure enzyme activity and to study metabolic disorders. Its role in nucleic acid synthesis and cellular metabolism makes it a valuable tool for understanding fundamental biological processes. The compound's versatility and specificity make it indispensable in advanced biochemical studies.
Safety and Storage
Adenosylhomocysteine should be handled with care to avoid inhalation or contact with skin and eyes. Proper personal protective equipment, such as gloves and lab coats, is recommended when working with the compound. SAH is hygroscopic and sensitive to light and moisture, requiring storage at -20°C in a dry, dark place to maintain stability. Disposal of SAH should comply with local regulations for chemical waste. The compound's stability under recommended storage conditions ensures its longevity and effectiveness in research applications. Always verify the integrity of the product upon delivery and monitor storage conditions to prevent degradation.
B2B Procurement Guide
When procuring Adenosylhomocysteine, prioritize suppliers with a proven track record in biochemical reagents. Verify the purity of the compound (≥95%) and request certificates of analysis to ensure quality. Storage conditions should be confirmed upon delivery to prevent degradation, as SAH is sensitive to moisture and light. Bulk purchases may offer cost savings, but ensure proper storage facilities are available. Compare prices from multiple suppliers, as the reference price range is approximately $50-$200 per gram, depending on purity and quantity. Establish long-term relationships with reliable suppliers to ensure consistent quality and availability for ongoing research needs.
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