Overview
Acetylthiol, also known as thioacetic acid, is an organosulfur compound characterized by the presence of a thiol group (-SH) and an acetyl group (-COCH3). It is commonly used as an intermediate in organic synthesis and pharmaceutical manufacturing. This compound is highly reactive due to its sulfur content, making it valuable for introducing thiol groups into other molecules. It is typically handled with care due to its corrosive nature and strong, unpleasant odor.
Physical and Chemical Properties
Acetylthiol is a colorless to pale yellow liquid with a pungent odor reminiscent of acetic acid and hydrogen sulfide. It has a molecular weight of 76.12 g/mol and a density of 1.07 g/cm³. The compound is soluble in water, alcohol, and ether, and it boils at approximately 93-95°C. Its reactivity is primarily due to the thiol group, which can participate in various chemical reactions, including nucleophilic substitutions and additions.
Main Applications
Acetylthiol is widely used in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. It serves as a key intermediate for introducing thiol groups into larger molecules, which are often bioactive. In the pharmaceutical industry, it is used to produce drugs with sulfur-containing functional groups. It also finds applications in the manufacture of rubber additives, corrosion inhibitors, and fragrances.
Safety and Storage
Acetylthiol is corrosive and can cause severe skin and eye irritation. Proper personal protective equipment (PPE), including gloves and goggles, should be worn when handling this compound. Storage should be in a cool, dry, well-ventilated area, away from oxidizing agents and incompatible materials. Containers must be tightly sealed to prevent leakage and exposure to moisture.
B2B Procurement Guide
When procuring acetylthiol, buyers should prioritize suppliers with a proven track record of quality and reliability. Key considerations include purity specifications, packaging integrity, and compliance with safety regulations. Bulk purchases may offer cost advantages, but storage conditions must be carefully managed. It is advisable to request material safety data sheets (MSDS) and certificates of analysis (CoA) to ensure product quality.
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