Overview
A-1331852 is a small molecule compound widely recognized for its role as a selective BCL-XL inhibitor. It is primarily utilized in biochemical and pharmaceutical research to study apoptosis and the BCL-2 family of proteins. The compound has shown promise in preclinical studies for its potential in cancer therapeutics, particularly in targeting cancer cell survival pathways. Due to its specificity, A-1331852 is a valuable tool for researchers investigating mechanisms of programmed cell death and developing novel anti-cancer strategies. Its molecular structure and binding affinity make it a subject of interest in drug discovery and development.
Physical and Chemical Properties
A-1331852 is a white to off-white powder with a molecular weight of 527.66 g/mol. It is soluble in common organic solvents such as DMSO, ethanol, and methanol, which facilitates its use in laboratory settings. The compound's stability under recommended storage conditions (-20°C, protected from light and moisture) ensures its longevity for research purposes. The molecular formula C31H37N5O3 reflects its complex structure, which is designed to selectively inhibit BCL-XL. While specific melting and boiling points are not widely documented, its solubility profile and stability are well-suited for experimental applications.
Main Applications
A-1331852 is predominantly used in biochemical research to investigate the role of BCL-XL in apoptosis and cancer cell survival. Its ability to selectively inhibit BCL-XL makes it a critical tool for studying the BCL-2 family of proteins, which are key regulators of cell death. In addition to basic research, A-1331852 is explored in preclinical studies for its potential therapeutic applications, particularly in cancers where BCL-XL overexpression contributes to resistance to apoptosis. Researchers also use it to develop combination therapies targeting multiple anti-apoptotic proteins.
Safety and Storage
Handling A-1331852 requires adherence to standard laboratory safety protocols, including the use of personal protective equipment (PPE) such as gloves and lab coats. The compound should be stored at -20°C in a tightly sealed container, protected from light and moisture to maintain stability. Disposal should follow institutional guidelines for hazardous chemical waste. Researchers should consult safety data sheets (SDS) for detailed handling and emergency measures to minimize risks associated with exposure.
B2B Procurement Guide
When procuring A-1331852, B2B buyers should prioritize suppliers that provide certificates of analysis (COA) to verify purity and quality. Given its specialized use, lead times may apply for bulk orders, and buyers should plan accordingly. Price ranges can vary significantly based on quantity and supplier, with reference prices approximately $500-$1,000 per 10 mg. Buyers are advised to compare offerings from multiple vendors and consider logistical factors such as shipping conditions to ensure product integrity upon arrival.
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