Overview
8-Oxoberberine Standard is a certified reference material (CRM) primarily used in pharmaceutical and biochemical research. As an oxidative metabolite of berberine, it serves as a critical quality control standard for herbal medicine analysis and drug metabolism studies. The compound is classified as a protoberberine alkaloid and is typically supplied with comprehensive certification including HPLC purity, spectral data, and batch-specific documentation. In B2B contexts, this standard is predominantly purchased by analytical laboratories, pharmaceutical manufacturers, and research institutions. Its primary value lies in enabling accurate quantification of berberine and its derivatives in complex matrices, ensuring compliance with pharmacopeial methods and research reproducibility standards.
Physical and Chemical Properties
8-Oxoberberine exhibits distinct chromophoric properties with maximum UV absorption between 265-270nm and 340-350nm, making it suitable for photometric detection methods. The compound demonstrates moderate stability under refrigeration but may degrade when exposed to prolonged light or elevated temperatures. Its fluorescence characteristics are particularly valuable for LC-MS applications in trace analysis. The crystalline structure contains a planar isoquinoline moiety with a conjugated ketone group at the 8-position, which contributes to its electrochemical activity. This structural feature allows for sensitive detection in oxidative electrochemical assays. Solubility varies significantly with solvent polarity, requiring methanol or DMSO for complete dissolution in laboratory preparations.
Main Applications
The standard's primary application is in quality control of berberine-containing herbal products, including Huanglian and other traditional medicines. It serves as a system suitability test compound in HPLC method validation for alkaloid analysis according to pharmacopeia standards. Research laboratories utilize it to study berberine's metabolic pathways, particularly its oxidation mechanisms in hepatic systems. In drug development, 8-Oxoberberine acts as a marker compound for bioavailability studies of berberine-based formulations. Recent applications extend to anti-diabetic and anti-inflammatory research, where it helps quantify active metabolites in biological samples. Analytical instrument manufacturers often include this standard in method development kits for natural product analysis.
Safety and Storage
As a laboratory chemical, 8-Oxoberberine Standard requires handling with basic PPE including gloves and safety goggles. Although not classified as acutely toxic, prolonged exposure should be avoided due to limited toxicological data. Spills should be contained with absorbent materials and cleaned with ethanol followed by water. Proper storage involves protection from moisture and light in amber glass vials with PTFE-lined caps. Long-term stability is maintained at 2-8°C with desiccant. Users should verify compound integrity through periodic UV spectrum checks, particularly after prolonged storage or exposure to temperature fluctuations during shipping.
B2B Procurement Guide
When procuring 8-Oxoberberine Standard, buyers should prioritize suppliers who provide batch-specific certificates of analysis (COA) with detailed chromatographic purity data (typically ≥98%). Essential documentation includes HPLC chromatograms, mass spectra, and water content analysis. For regulated applications, ensure the supplier can provide current GMP compliance statements. Bulk purchases (1g+) may offer cost savings of 20-40% compared to small quantities, but stability considerations limit practical order sizes for most users. Lead times vary from 2-6 weeks depending on purification requirements. Some suppliers offer customized solutions including pre-prepared stock solutions or isotope-labeled versions for advanced research applications.
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