Overview
8-Fluoroquinoline is a fluorinated heterocyclic compound derived from quinoline, where a fluorine atom is substituted at the 8-position. It serves as a versatile intermediate in organic synthesis, particularly in pharmaceutical and agrochemical industries. Due to its unique electronic properties imparted by the fluorine substituent, it is often used to modify the biological activity of quinoline-based compounds. The presence of fluorine can enhance metabolic stability and binding affinity in drug molecules.
Physical and Chemical Properties
8-Fluoroquinoline appears as a pale yellow to colorless crystalline solid with a molecular weight of 147.15 g/mol. It is soluble in common organic solvents like ethanol and ether but exhibits negligible solubility in water. The compound is relatively stable under standard conditions but may decompose under strong oxidizing agents. Its melting point ranges between 40-45°C, and it boils at approximately 220-225°C. The fluorine atom at the 8-position influences its reactivity, making it useful for selective functionalization.
Main Applications
The primary use of 8-fluoroquinoline is as a building block in pharmaceutical synthesis. It is employed in the development of antibacterial, antiviral, and anticancer agents, leveraging the quinoline scaffold's bioactive properties. In agrochemical research, it serves as an intermediate for designing novel pesticides and herbicides. Additionally, it finds applications in material science, such as in the synthesis of fluorescent dyes and organic electronic materials.
Safety and Storage
8-Fluoroquinoline is classified as an irritant, requiring careful handling to avoid skin or eye contact. Personal protective equipment (PPE), including gloves and goggles, is recommended during use. Store the compound in a tightly sealed container in a cool, dry place, away from direct sunlight and moisture. Incompatible with strong oxidizers and bases. Always refer to the Material Safety Data Sheet (MSDS) for detailed hazard and disposal guidelines.
B2B Procurement Guide
When procuring 8-fluoroquinoline, prioritize suppliers with certified quality control and transparent documentation. Key specifications to verify include purity (≥98%), CAS number (394-68-3), and batch-specific analytical reports. For bulk purchases, negotiate pricing based on volume, and ensure compliance with regional chemical regulations. Request samples for in-house testing before large-scale orders. Reliable suppliers often provide technical support and customized packaging options.
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