Overview
Octa-Arm PEG-Silane is a specialized polyethylene glycol (PEG) derivative featuring eight reactive silane-terminated arms. This structure enables it to act as a versatile crosslinker in biomedical and industrial applications. The compound is prized for its biocompatibility, water solubility, and ability to form stable bonds with various substrates. Its multifunctional design allows for high-density conjugation, making it ideal for creating advanced materials such as hydrogels and surface coatings. The PEG backbone ensures low immunogenicity, while the silane groups provide robust anchoring to surfaces like glass, metals, and polymers.
Physical and Chemical Properties
Octa-Arm PEG-Silane typically appears as a white powder or viscous liquid, depending on its molecular weight and formulation. It is highly soluble in water and polar solvents like DMSO, ethanol, and acetone. The compound’s reactivity is driven by its silane termini, which hydrolyze in the presence of moisture to form silanol groups, enabling covalent bonding to hydroxyl-rich surfaces. Its PEG backbone confers flexibility and hydrophilicity, while the eight-arm structure enhances crosslinking efficiency. The molecular weight varies based on the PEG chain length, commonly ranging from 5,000 to 20,000 g/mol. Stability is a key consideration; the compound should be stored under anhydrous conditions to prevent premature hydrolysis.
Main Applications
Octa-Arm PEG-Silane is extensively used in biomedical research and industrial processes. In bioconjugation, it serves as a linker for attaching biomolecules like proteins, peptides, and nucleic acids to surfaces or other molecules. Its ability to form hydrogels makes it valuable in tissue engineering and drug delivery systems, where controlled release and scaffold stability are critical. In industrial settings, the compound is employed for surface modification of materials such as glass, silicon, and metals, enhancing adhesion and biocompatibility. It is also used in coatings for medical devices and sensors, where durability and low fouling properties are essential.
Safety and Storage
Handling Octa-Arm PEG-Silane requires precautions due to its moisture sensitivity and reactivity. It should be stored in a tightly sealed container under inert gas (e.g., argon or nitrogen) at -20°C to prevent hydrolysis. Exposure to moisture or humidity can degrade its performance. Personal protective equipment (PPE), including gloves and safety goggles, is recommended during use. The compound is generally low-toxicity but should be used in a well-ventilated area. Spills should be contained and cleaned promptly with absorbent materials, followed by rinsing with water or ethanol.
B2B Procurement Guide
When procuring Octa-Arm PEG-Silane, buyers should specify key parameters such as PEG chain length, purity (typically >95%), and functional group density. Reputable suppliers should provide certificates of analysis (CoA) and material safety data sheets (MSDS). Bulk purchases may offer cost savings, but storage conditions must be ensured to maintain product integrity. Custom modifications, such as end-capping or additional functional groups, are available from specialized manufacturers. Lead times can vary, so advance planning is advisable for large-scale orders.
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