Overview
7-O-β-D-Glucuronide is a glucuronide conjugate, a type of glycoside formed by the linkage of β-D-glucuronic acid to another molecule via a glycosidic bond. It is commonly found in plant metabolites and is a significant intermediate in drug metabolism. This compound plays a crucial role in detoxification processes by increasing the solubility of various compounds, facilitating their excretion from the body. In biochemical and pharmaceutical research, 7-O-β-D-Glucuronide is used as a standard or reference compound due to its stability and well-characterized properties. Its presence in herbal medicines and natural products makes it a valuable biomarker for quality control and metabolic studies.
Physical and Chemical Properties
7-O-β-D-Glucuronide typically appears as a white to off-white powder with high solubility in water and polar organic solvents. Its molecular formula is C12H18O8, with a molecular weight of 290.27 g/mol. The compound is stable under physiological conditions, making it suitable for various research applications. The glucuronide moiety enhances the hydrophilicity of parent compounds, which is why it is often involved in phase II metabolism. This property is particularly useful in drug development, where improving the solubility of hydrophobic drugs is a common challenge. The compound's stability and solubility profile make it a preferred choice for in vitro and in vivo studies.
Main Applications
7-O-β-D-Glucuronide is primarily used in drug metabolism studies to understand the biotransformation of pharmaceuticals. It serves as a reference standard in pharmacokinetic and pharmacodynamic research. Additionally, it is employed in herbal medicine research to identify and quantify glucuronide conjugates in plant extracts. In biochemical assays, this compound acts as a biomarker for enzymatic activity, particularly for glucuronosyltransferases. Its role in detoxification processes is also studied in toxicology, where it helps in understanding the metabolism of xenobiotics. The compound's applications extend to quality control in the pharmaceutical and nutraceutical industries.
Safety and Storage
7-O-β-D-Glucuronide is generally considered safe when handled under standard laboratory conditions. It is non-toxic and does not pose significant health risks under normal use. However, proper laboratory practices, such as wearing gloves and eye protection, should be followed to avoid unnecessary exposure. The compound should be stored in a cool, dry place away from light and moisture to maintain its stability. Long-term storage may require refrigeration or freezing, depending on the supplier's recommendations. Proper labeling and segregation from incompatible chemicals are essential to ensure safety and integrity.
B2B Procurement Guide
When procuring 7-O-β-D-Glucuronide, it is essential to verify the purity and authenticity of the product. Reputable suppliers should provide certificates of analysis (CoA) detailing the compound's purity, molecular weight, and other relevant specifications. The reference price range is approximately $100-$500 per gram, depending on purity and supplier. Bulk procurement may offer cost advantages, but it is advisable to start with smaller quantities to assess suitability for specific applications. Ensure that the supplier complies with Good Manufacturing Practices (GMP) if the compound is intended for pharmaceutical use. Proper documentation and traceability are critical for regulatory compliance.
Related Manufacturers
- 主营：夹竹桃、异奥卡、香附酮、管花苷、皂苷元、樱桃苷、儿茶素、白鲜碱、紫檀芪、木栓醇、豆甾醇、植酸锌、苏木素、泽泻醇、龙血素、黄柏酮、蚱蜢酮、防己碱、葫芦素、乌甲素、印楝素、厚朴酚、标准品、双黄酮、芝麻素
- 主营：β-香树脂酮、桉脂素、化学试剂
- 主营：香叶木素7、对照品、标准品
- 主营：中药标准品、标准品对照品、天然化合物、葡萄糖醛酸苷、标准品、分析试剂、细胞实验、动物实验、中药提取物、单体化合物、科研实验用
- 主营：千金子、大黄素、千里光菲灵碱、紫茎女贞苷b、花青素、甘草系列、水飞蓟系列
- 主营：精萃宝对照品、一叶萩碱、羟基红花黄色素A、三叶豆紫檀苷、松果菊苷、马钱苷、莫诺苷、苍术素、苍术酮、盐酸血根碱、盐酸白屈菜红碱、药根碱、藁本内酯、欧当归内酯A、高丽槐素
- 主营：对照品、标准品、姜烯酚、三叶苷、人参皂苷、地黄苷、科研试剂、实验室自制、生育三烯酚
- 主营：甲基原、钩藤碱、络塞定、2086-83-1、6836-11-9、管花苷、6926-08-5、3668-14-2、白麻苷、秦皮苷、葛花苷、柚皮苷、丹皮酚、鞣花酸、川楝素、黄芩素、苍术素、松脂素、熊果酸、苦参碱、土莫酸、苜蓿素、茯苓酸、柚皮素、山奈酚
- 主营：钩藤碱、丹皮酚、高良姜、c17h26o10、管花苷、白麻苷、络石苷、木皂苷、皂苷rg2、丹参酮、鞣花酸、川楝素、苍术素、芦竹碱、苦参碱、土贝母、柚皮素、甜菜碱、紫草素、苏木素、甘露糖、番茄碱、青蒿酸、芹菜素、紫杉醇
- 主营：标准品、中药对照品、试剂、精油、技术服务、提取定制、化合物合成、分析检测、色谱柱、天然产物
- 主营：芍药素、花姜酮、氨基辛酸、葡萄糖苷、半乳糖苷、阿拉伯糖苷、飞燕草素、天竺葵素、矮牵牛素、天竺葵色素、去氢钩藤碱、氯化锦葵色素
- 主营：葡萄糖醛酸苷、白蜡树素、百两金素、半齿泽兰素
- 主营：酒渣碱、异常山乙素、芦丁标准品、葡萄糖醛酸苷、对照品标准品
- 主营：标准品、中药对照品、槲皮万寿菊素、葡萄糖醛酸苷、新绿原酸
- 主营：标准品、细辛脂素、百两金素、桃叶珊瑚苷、延胡索乙素、脱氢紫堇碱