Overview
7β-Hydroxyganoderic Acid F is a triterpenoid compound extracted from Ganoderma lucidum, commonly known as Reishi mushroom. It belongs to the ganoderic acid family, which is renowned for its bioactive properties. This compound is of significant interest in pharmacological research due to its potential therapeutic effects, including anti-inflammatory, antitumor, and hepatoprotective activities. Research suggests that 7β-Hydroxyganoderic Acid F modulates cellular pathways involved in inflammation and apoptosis, making it a candidate for drug development. Its natural origin and low toxicity profile further enhance its appeal for nutraceutical applications.
Physical and Chemical Properties
7β-Hydroxyganoderic Acid F is a white to off-white crystalline powder with a molecular formula of C30H44O7 and a molecular weight of 516.67 g/mol. It is lipophilic and dissolves well in organic solvents like ethanol and dimethyl sulfoxide (DMSO), but has limited solubility in water. The compound is sensitive to light, heat, and moisture, requiring storage at low temperatures (-20°C) in airtight containers. Stability studies indicate that it degrades under prolonged exposure to high temperatures or acidic/basic conditions, necessitating careful handling during laboratory use.
Main Applications
The primary application of 7β-Hydroxyganoderic Acid F lies in pharmaceutical and nutraceutical research. It is studied for its ability to inhibit pro-inflammatory cytokines and suppress tumor cell proliferation, making it a potential adjunct in cancer therapy and chronic inflammatory diseases. In traditional medicine, extracts containing this compound are used to support liver health and immune function. Additionally, it is incorporated into dietary supplements targeting oxidative stress and aging-related conditions. Industrial-scale production remains limited, with most supplies catering to academic and clinical research.
Safety and Storage
While 7β-Hydroxyganoderic Acid F exhibits low acute toxicity, proper safety measures are essential. Use gloves, goggles, and lab coats to avoid skin or eye contact. Inhalation of powder should be prevented with fume hoods or masks. Storage requires protection from light and moisture. Long-term stability is best maintained at -20°C in amber glass vials with desiccants. Avoid repeated freeze-thaw cycles, as this may degrade the compound. Disposal should follow local regulations for organic waste.
B2B Procurement Guide
When procuring 7β-Hydroxyganoderic Acid F, prioritize suppliers with certified analytical reports (e.g., HPLC purity ≥98%). Reputable manufacturers often provide mass spectrometry (MS) and nuclear magnetic resonance (NMR) data for verification. Bulk purchases for research may qualify for discounts, but confirm scalability and batch consistency. Prices vary widely ($100-$500/g) based on purity and supplier reputation. For regulatory compliance, ensure documentation includes safety data sheets (SDS) and certificates of analysis (CoA). Consider lead times, as custom synthesis can take weeks.
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