6-Nitroquinoxaline

Updated: 2026-07-29

Overview

6-Nitroquinoxaline is a nitro-substituted derivative of quinoxaline, a heterocyclic compound. It is primarily used as an intermediate in pharmaceutical and agrochemical research. The compound is known for its role in synthesizing more complex molecules, particularly in medicinal chemistry. Its molecular structure includes a quinoxaline ring system with a nitro group at the 6-position, which influences its reactivity and applications. The compound is typically supplied as a yellow crystalline powder, making it easy to handle in laboratory settings.

Physical and Chemical Properties

6-Nitroquinoxaline is a yellow crystalline solid with a molecular weight of 175.14 g/mol. It has a melting point range of approximately 160-165°C, which is typical for nitro-substituted heterocycles. The compound is soluble in common organic solvents like ethanol, acetone, and dimethyl sulfoxide (DMSO), but only slightly soluble in water. Its chemical stability under normal conditions makes it suitable for various synthetic applications. However, like many nitro compounds, it may decompose under strong heat or prolonged exposure to light, releasing hazardous gases. Proper storage and handling are essential to maintain its integrity.

Main Applications

6-Nitroquinoxaline is widely used as a building block in pharmaceutical research, particularly in the development of drugs targeting neurological disorders. Its nitro group makes it a versatile intermediate for further chemical modifications, such as reduction to amino derivatives. In agrochemical research, the compound is explored for its potential as a precursor to herbicides and pesticides. Additionally, it finds use in dye synthesis, where its nitro group contributes to color formation. The compound's applications are largely confined to research and development, with limited large-scale industrial use.

Safety and Storage

6-Nitroquinoxaline requires careful handling due to its potential health hazards. Inhalation, ingestion, or skin contact should be avoided, as it may cause irritation or more severe health effects. Laboratory personnel should use gloves, goggles, and protective clothing when working with this compound. Storage conditions are critical to maintaining its stability. The compound should be kept in a cool, dry place, away from direct light and moisture. Containers must be tightly sealed to prevent contamination or degradation. A safety data sheet (SDS) should always be consulted before use.

B2B Procurement Guide

When procuring 6-Nitroquinoxaline, B2B buyers should prioritize suppliers with a proven track record in chemical manufacturing. Key factors to consider include purity (typically 95% or higher), packaging (sealed containers to prevent moisture ingress), and compliance with regulatory standards. Prices vary depending on quantity and purity, ranging from approximately $50 to $100 per gram. Bulk purchases may qualify for discounts. Buyers should request certificates of analysis (CoA) and SDS to ensure product quality and safety. Lead times can vary, so advance planning is recommended.