Overview
6-Nitroindolin-2-one is an organic compound belonging to the indole family, characterized by a nitro group at the 6-position of the indolin-2-one structure. It serves as a versatile intermediate in pharmaceutical and agrochemical synthesis. This compound is primarily utilized in research and industrial applications due to its reactivity and role in constructing complex molecules. Its synthesis typically involves nitration of indolin-2-one derivatives under controlled conditions.
Physical and Chemical Properties
6-Nitroindolin-2-one appears as a light yellow to yellow crystalline powder with a molecular weight of 178.15 g/mol. It is soluble in polar organic solvents like DMSO but has limited solubility in water. The compound exhibits stability under standard conditions but may decompose at high temperatures. Its melting point ranges between 220-225°C, and it should be protected from moisture and light to prevent degradation.
Main Applications
6-Nitroindolin-2-one is widely used as a building block in pharmaceutical synthesis, particularly for drugs targeting neurological and anti-inflammatory pathways. It also finds applications in agrochemicals for developing pesticides and herbicides. In research, it serves as a precursor for synthesizing indole-based compounds with potential biological activity. Its nitro group enables further functionalization, making it valuable in organic chemistry.
Safety and Storage
Handling 6-Nitroindolin-2-one requires precautions due to its potential irritant properties. Use gloves, goggles, and lab coats to avoid skin or eye contact. Work in a fume hood to minimize inhalation risks. Store the compound in a tightly sealed container in a cool, dry place away from direct sunlight and incompatible substances like strong oxidizing agents. Dispose of waste according to local regulations.
B2B Procurement Guide
When procuring 6-Nitroindolin-2-one, prioritize suppliers with certifications (e.g., ISO, GMP) and transparent quality control processes. Request certificates of analysis (CoA) to verify purity (typically ≥95% by HPLC). Bulk buyers should negotiate pricing based on quantity and purity requirements. Consider logistics, such as temperature-controlled shipping for large orders, to maintain product integrity.
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