Overview
6-Nitroindole is a nitro-substituted derivative of indole, a heterocyclic aromatic compound. It is widely used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and dyes. The presence of the nitro group enhances its reactivity, making it a valuable building block in organic chemistry. This compound is typically available as a yellow to brown crystalline powder. Its applications span across research laboratories and industrial settings, where it serves as a precursor for more complex molecules. Due to its specialized use, it is often procured by B2B buyers in the chemical and pharmaceutical industries.
Physical and Chemical Properties
6-Nitroindole has a molecular weight of 162.15 g/mol and a melting point range of 150-155°C. It is soluble in organic solvents such as ethanol and dimethyl sulfoxide (DMSO), but only slightly soluble in water. The nitro group attached to the indole ring imparts significant reactivity, which is leveraged in various chemical reactions. The compound's stability is influenced by storage conditions. Exposure to light, moisture, or high temperatures can degrade its quality. Proper handling is essential to maintain its chemical integrity, especially in industrial applications where consistency is critical.
Main Applications
6-Nitroindole is primarily used as an intermediate in the pharmaceutical industry, where it contributes to the synthesis of active pharmaceutical ingredients (APIs). Its nitro group facilitates further chemical modifications, enabling the creation of diverse molecular structures. In agrochemicals, it serves as a precursor for herbicides and pesticides. Additionally, its role in dye synthesis highlights its versatility. The compound's reactivity makes it a preferred choice for researchers and manufacturers seeking to develop specialized chemicals with precise properties.
Safety and Storage
Due to its irritant properties, 6-Nitroindole requires careful handling. Protective equipment such as gloves, goggles, and lab coats should be worn to prevent skin and eye contact. Inhalation of dust or fumes should be avoided by working in a well-ventilated area or under a fume hood. Storage conditions are critical to preserving its quality. The compound should be kept in a cool, dry place, away from light and moisture. Sealed containers are recommended to minimize exposure to air, which could lead to degradation over time.
B2B Procurement Guide
When procuring 6-Nitroindole, buyers should verify the CAS number (6146-52-7) and purity specifications. Reputable suppliers often provide certificates of analysis (CoA) to confirm quality. Bulk orders may require custom synthesis, so lead times should be accounted for in procurement planning. Price ranges vary based on purity and supplier, with reference prices typically between $50 and $200 per gram. Buyers should also consider logistical factors such as shipping conditions and storage requirements to ensure the product arrives in optimal condition.
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