Overview
6-Methoxy-2-naphthylacetic acid (6-MNAA) is an organic compound belonging to the naphthalene acetic acid family. It serves as a valuable intermediate in pharmaceutical synthesis, particularly in the production of non-steroidal anti-inflammatory drugs (NSAIDs). The compound features a methoxy group at the 6-position and a carboxylic acid group at the 2-position on the naphthalene ring, giving it distinct chemical properties that make it useful for various synthetic applications. First synthesized in the mid-20th century, 6-MNAA has gained importance in medicinal chemistry due to its role as a precursor for more complex pharmaceutical compounds. Its structural characteristics allow for specific interactions in biochemical pathways, making it particularly valuable in research settings focused on inflammation and pain management mechanisms.
Physical and Chemical Properties
6-Methoxy-2-naphthylacetic acid presents as a white to off-white crystalline powder with a characteristic mild odor. It demonstrates moderate solubility in polar organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO), while being only slightly soluble in water. The compound shows good thermal stability below its melting point range of 156-160°C, making it suitable for various synthetic processes. Chemically, 6-MNAA exhibits typical carboxylic acid behavior, capable of forming salts with bases and esters with alcohols. The electron-donating methoxy group at the 6-position influences the compound's electronic distribution, affecting its reactivity in electrophilic substitution reactions. These properties are particularly important when the compound is used as a building block in pharmaceutical synthesis.
Main Applications
The primary application of 6-Methoxy-2-naphthylacetic acid lies in pharmaceutical synthesis, where it serves as a key intermediate in the production of naproxen and related NSAIDs. Pharmaceutical manufacturers value this compound for its structural features that can be modified to create potent anti-inflammatory medications. The compound's specific arrangement of functional groups allows for targeted modifications while maintaining desired biological activity. Beyond pharmaceutical manufacturing, 6-MNAA finds use in biochemical research as a tool compound for studying inflammatory pathways. Some specialized applications include its use in the synthesis of fluorescent probes and as a reference standard in analytical chemistry. Research laboratories may employ this compound in studies investigating structure-activity relationships of anti-inflammatory agents.
Safety and Storage
Proper handling of 6-Methoxy-2-naphthylacetic acid requires standard laboratory precautions including gloves, protective eyewear, and appropriate ventilation. The compound may cause skin and eye irritation upon contact, and inhalation of dust should be avoided. In case of exposure, affected areas should be flushed with plenty of water, and medical attention sought if irritation persists. For storage, 6-MNAA should be kept in tightly sealed containers under cool (2-8°C), dry conditions, protected from light exposure to maintain stability. Long-term storage should be in amber glass bottles or light-resistant containers. The compound shows good stability when stored properly, with typical shelf life of 2-3 years when uncontaminated and kept under recommended conditions.
B2B Procurement Guide
When procuring 6-Methoxy-2-naphthylacetic acid in bulk quantities, pharmaceutical manufacturers and research institutions should prioritize suppliers with documented quality control processes. Key specifications to verify include purity (typically ≥98%), residual solvent content, and heavy metal contamination levels. Pharmaceutical-grade material requires additional documentation including detailed certificates of analysis (COA) and potentially DMF filings. Lead times for custom synthesis can vary from 4-12 weeks depending on quantity and purity requirements. Minimum order quantities for research-grade material typically start at 10 grams, while industrial-scale purchases may require kilogram quantities. For international shipments, proper customs documentation should be arranged in advance, particularly for pharmaceutical-grade material which may require special import permits.
Related Manufacturers
- 主营：β-香树脂酮、桉脂素、化学试剂
- 主营：甲氧基、对照品、标准品
- 主营：阻燃剂、拉那白、牛儿酮、26、海藻糖、热敏蓝、萘磺酸、氯菊酯、硫酸锌、催化剂、杨梅酯、檀香醚、聚醚胺、吸收剂、脂檀油、苍术素、羟钴胺、转移剂、溶剂绿、麝香酮、王浆酸、芬多精、纤维素、新戊酯、王冠醚、遮甜粉
- 主营：石油醚、四氢噻吩、顺酐、苯酐
- 主营：聚苯胺、脯氨酸甲酯盐酸盐、苄基三甲基氯化铵
- 主营：聚乙烯亚胺、三甘醇二异辛酸酯3G8、三硫代碳酸钠40%、TS-1钛硅分子筛、5-甲基靛红、六氯环三磷腈、烷基苯磺酸酯、苯基次磷酸钠、甲巯咪唑、吡啶硫酮锌、焦磷酸哌嗪、热敏材料、油酸甲酯、曲酸
- 主营：离子液体、咪唑、催化剂、5-二甲基吡唑、全氟辛基三甲氧基硅烷、阻燃剂、正丁醇锆、四氟硼酸锂、香兰基丁醚、氟化物、丙酮肟、双酚E型氰酸酯、叔丁基乙烯基醚、钯碳催化剂、钛硅分子筛、硫酸烟酰苯胺、丙酮缩氨基硫脲
- 主营：全氟三丁胺、二苄叉山梨醇、六氟丙烯二聚体、甲氧基、六氟环氧丙烷二聚体、异丙醇铝、纳米勃姆石、二异戊基硫醚、隐色结晶紫、邻菲罗啉
- 主营：架桥剂、YW100 锂萃取剂、端羧基液体丁腈橡胶、10-羟基癸酸、β-磷酸三钙、1-乙炔基环已醇、苯乙烯磷酸、肉豆蔻酸镁、硬脂酸钴、全氟三丁胺、乙烯基磷酸二乙酯、磷酸锰铁锂、十一烯酸、钨酸铝、间二异丙苯、锂硅合金、溴甲酚绿、生物活性玻璃、溴代海因树脂颗粒、红铝、龙涎酮、原丁酸三甲酯
- 主营：甲氧基、麦芽糖酸、苯氧基环磷腈、甲巯基四氮唑
- 主营：催化剂、胆酸、氧化剂、6-二羟基吲哚、6-羟基吲哚、N-乙基哌嗪、L-脯氨酸、酶类、光引发剂、生物缓冲剂、交联剂、光敏剂、樟脑醌、十二氢十二硼双钠盐、磷钼酸、钼酸钾、荧光增白剂、葡甲胺、鹅去氧胆酸、石胆酸
- 主营：聚乙二醇、聚丙二醇、叔胺、甲氧基、伯胺、染料中间体
- 主营：阻燃剂、乙酸镍、乙酸镝、甲氧基、硫酸锂、硫酸锶、溴氨酸、香茅醇、肌氨酸、锂电池、四氢萘、磷酸铬、碳酸镁、碳酸镍、防冻剂、磷酸铝、叔丁醇、氟苯基、浮选剂、稀释剂、羟乙基、去除剂、庚二酸、除磷剂、十八烯、蛋白酶
- 主营：磷钼酸、艾拉莫德中间体、甲基丙二酸、6-二羟基吲哚、β-丙氨酸甲酯盐酸盐、7-去氢胆固醇、2-辛基十二醇、D-荧光素钾盐、BIS-TRIS、光引发剂、苯芴醇、溴芬酸钠中间体、樟脑醌、钼酸钾、丝素蛋白、盐酸胍、聚二羟基吲哚、甘氨胆酸钠盐、半叶素、胆固醇、蛋白酶K、光引发剂LAP、甲基丙烯酸氧杂环丁烷
- 主营：壬二酸、羟乙基、三胜肽、302776-68-7、玻色因、依克多因、抗坏血酸、谷胱甘肽、苯甲酸己酯、葡糖基芦丁、紫外吸收剂、辛氧基甘油、生物素三肽、乙酰基四肽、棕榈酰三肽、肉豆蔻酰五肽、植物油脂肪酸、氨基羟苯甲酰、紫外线吸收剂、维生素c乙基醚、二氢燕麦生物碱、苯乙基间苯二酚、水杨酸乙基己酯、乙基己基三嗪酮