Overview
6-Hydroxykaempferol is a naturally occurring flavonoid derivative of kaempferol, distinguished by an additional hydroxyl group at the 6-position. It is found in various medicinal plants and exhibits notable biological activities, including antioxidant and anti-inflammatory effects. This compound is of interest to the pharmaceutical and cosmetic industries due to its potential therapeutic benefits and role in skincare formulations. Structurally, it belongs to the flavone subclass of flavonoids, characterized by a 15-carbon skeleton with two phenyl rings and a heterocyclic ring. Its chemical stability and solubility profile make it suitable for use in both aqueous and organic solvent-based applications.
Physical and Chemical Properties
6-Hydroxykaempferol is a yellow crystalline solid with a molecular weight of 302.24 g/mol. Its melting point ranges between 250-260°C, and it demonstrates good solubility in polar organic solvents like methanol and ethanol, though it is only sparingly soluble in water. The compound is sensitive to prolonged exposure to light and heat, which may degrade its efficacy. Key chemical properties include its ability to scavenge free radicals, attributed to the presence of multiple hydroxyl groups. This feature underpins its antioxidant capacity, which is often measured via assays like DPPH or ORAC. The compound's stability under varying pH conditions is also a critical factor for formulation in commercial products.
Main Applications
In the pharmaceutical sector, 6-Hydroxykaempferol is investigated for its potential in treating oxidative stress-related diseases, such as cardiovascular disorders and neurodegenerative conditions. Its anti-inflammatory properties make it a candidate for topical creams targeting skin inflammation or aging. The nutraceutical industry incorporates this flavonoid into dietary supplements for its purported health benefits, including immune support. Cosmetic formulations leverage its antioxidant properties to protect skin from environmental damage, often appearing in serums and anti-aging products. Research is ongoing to explore its synergistic effects with other bioactive compounds.
Safety and Storage
While 6-Hydroxykaempferol is generally considered safe at low concentrations, proper handling is essential to avoid irritation. Use personal protective equipment (PPE) such as gloves and goggles when working with the powder form. In case of accidental exposure, rinse affected areas with water and seek medical advice if necessary. Storage requires protection from light and moisture to prevent degradation. Ideal conditions include airtight containers in a cool (below 25°C), dry environment. Bulk quantities should be stored in amber glass or opaque HDPE containers with desiccants to extend shelf life, typically up to two years under optimal conditions.
B2B Procurement Guide
When sourcing 6-Hydroxykaempferol, prioritize suppliers with certifications like ISO or GMP to ensure quality compliance. Request certificates of analysis (CoA) for each batch, detailing purity (≥95% by HPLC), residual solvents, and heavy metal content. Consider suppliers offering scalable production to meet fluctuating demand. Pricing varies based on purity and order volume, with bulk purchases (kilograms) often discounted. Sample testing is recommended before large-scale procurement to verify compatibility with your application. Logistics should account for temperature-controlled shipping if required, especially for international transactions.
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