Overview
6-Hydroxyindole is an aromatic heterocyclic compound derived from indole, featuring a hydroxyl group at the 6-position. It is a versatile intermediate in organic synthesis and pharmaceutical research. The compound is commonly used in the development of bioactive molecules and as a building block for more complex chemical structures. Its significance in medicinal chemistry stems from its ability to mimic natural indole derivatives, which are prevalent in many biologically active compounds. Researchers value 6-Hydroxyindole for its reactivity and potential applications in drug discovery and development.
Physical and Chemical Properties
6-Hydroxyindole appears as an off-white to light brown powder with a molecular weight of 133.15 g/mol. It is soluble in common organic solvents such as ethanol and methanol but has limited solubility in water. The compound has a melting point range of approximately 130-135°C. Chemically, 6-Hydroxyindole exhibits typical indole reactivity, including electrophilic substitution at the 5-position. The hydroxyl group enhances its polarity and makes it a useful intermediate for further functionalization. Its stability under standard conditions makes it suitable for various synthetic applications.
Main Applications
6-Hydroxyindole is primarily used in pharmaceutical research as a precursor for the synthesis of bioactive molecules. It serves as a key intermediate in the production of drugs targeting neurological and inflammatory conditions. The compound's structure is also explored in the development of dyes and pigments. In addition to pharmaceuticals, 6-Hydroxyindole finds applications in biochemical research, where it is used to study enzyme interactions and metabolic pathways. Its versatility makes it a valuable tool for chemists and researchers in both academic and industrial settings.
Safety and Storage
6-Hydroxyindole should be handled with care to avoid exposure. Proper personal protective equipment, including gloves and goggles, is recommended. The compound should be stored in a cool, dry place, away from light and moisture, to maintain its stability. In case of skin contact, wash thoroughly with soap and water. Avoid inhalation of dust and ensure adequate ventilation in the workspace. Disposal should comply with local regulations for chemical waste.
B2B Procurement Guide
When procuring 6-Hydroxyindole, buyers should prioritize suppliers with a proven track record of quality and reliability. Verify the compound's purity through certificates of analysis (CoA) and consider bulk purchasing for cost efficiency. Pricing varies based on purity and order volume, typically ranging from $50 to $200 per gram. Establish long-term relationships with trusted suppliers to ensure consistent quality and availability. Request samples for testing before large-scale purchases and confirm shipping and storage conditions to prevent degradation during transit.
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