Overview
2,6-Dibromopyridine is a brominated derivative of pyridine, characterized by two bromine atoms at the 2 and 6 positions of the pyridine ring. This compound is a versatile intermediate in organic synthesis, particularly in the pharmaceutical and agrochemical industries. Its reactivity makes it valuable for constructing complex molecules through cross-coupling reactions. The demand for 2,6-dibromopyridine has grown due to its role in synthesizing active pharmaceutical ingredients (APIs) and specialty chemicals. It is typically supplied as a white to off-white crystalline powder with high purity, ensuring consistent performance in synthetic applications.
Physical and Chemical Properties
2,6-Dibromopyridine exhibits a molecular weight of 236.89 g/mol and a melting point range of 110-112°C. It is soluble in common organic solvents such as ethanol, dimethyl sulfoxide (DMSO), and dichloromethane, but has limited solubility in water. The bromine substituents enhance its reactivity, making it a suitable substrate for palladium-catalyzed coupling reactions. Its crystalline form ensures stability under proper storage conditions, though exposure to moisture or light may degrade the compound. The presence of bromine atoms also contributes to its distinct spectroscopic properties, which are useful for identification and quality control.
Main Applications
2,6-Dibromopyridine is primarily used as a building block in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. It serves as a key intermediate in the production of active pharmaceutical ingredients (APIs) for drugs targeting neurological and cardiovascular diseases. In agrochemicals, it is employed to create herbicides and pesticides with enhanced efficacy. Additionally, its reactivity in cross-coupling reactions, such as Suzuki and Stille couplings, makes it valuable for constructing complex organic frameworks in materials science and catalysis.
Safety and Storage
Handling 2,6-dibromopyridine requires precautions due to its potential to cause skin and eye irritation. Personal protective equipment (PPE), including gloves and safety goggles, is recommended. Work should be conducted in a well-ventilated area or fume hood to avoid inhalation of dust. Storage conditions are critical to maintaining stability. The compound should be kept in a tightly sealed container, away from light, moisture, and incompatible materials. Long-term storage at room temperature is acceptable if these conditions are met.
B2B Procurement Guide
When procuring 2,6-dibromopyridine, verify the CAS number (626-05-1) and purity (typically ≥98%). Reputable suppliers often provide certificates of analysis (CoA) to confirm quality. Bulk purchases may require advance notice due to limited stock availability. Price varies based on purity and quantity, with reference ranges of $50-$200 per gram. Consider sourcing from specialized chemical distributors or manufacturers with a track record in halogenated pyridines. Ensure compliance with local regulations for hazardous material transport and storage.
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