6-Chloro-3-nitro-2-pyridinecarboxylic acid
Overview
6-Chloro-3-nitro-2-pyridinecarboxylic acid is a nitropyridine derivative with significant applications in fine chemical synthesis. Its molecular structure combines a carboxylic acid group with chloro and nitro substituents, making it a versatile intermediate for pharmaceutical and agrochemical manufacturing. The compound is primarily used in research and industrial settings for the development of specialized organic molecules. Its synthesis typically involves nitration and chlorination steps, followed by purification to achieve the desired purity level.
Physical and Chemical Properties
This compound appears as a light yellow to beige crystalline powder with a molecular weight of 202.55 g/mol. It decomposes at temperatures around 180-185°C and is soluble in polar organic solvents like dimethyl sulfoxide (DMSO) and methanol. The presence of both electron-withdrawing groups (nitro and chloro) and a carboxylic acid functional group contributes to its reactivity. These properties make it suitable for further chemical modifications, such as amidation or esterification, in synthetic pathways.
Main Applications
6-Chloro-3-nitro-2-pyridinecarboxylic acid serves as a key intermediate in the synthesis of pharmaceutical compounds, particularly those targeting central nervous system disorders or infectious diseases. Its structural features allow for the creation of complex molecules with specific biological activities. In agrochemicals, it is used to develop novel pesticides and herbicides. The compound's reactivity enables the formation of active ingredients that target specific pests or weeds while minimizing environmental impact.
Safety and Storage
Proper handling of 6-chloro-3-nitro-2-pyridinecarboxylic acid requires personal protective equipment, including gloves, goggles, and lab coats. The compound should be used in a well-ventilated area or fume hood to prevent inhalation of dust particles. For storage, maintain the material in its original container, tightly sealed, and protected from light and moisture. The recommended storage temperature range is 2-8°C to ensure long-term stability. Keep away from oxidizing agents and strong bases.
B2B Procurement Guide
When procuring this chemical for industrial or research purposes, verify the supplier's quality control processes and request certificates of analysis (CoA). The CoA should confirm the compound's identity (via HPLC or NMR), purity (typically ≥95%), and absence of significant impurities. Consider ordering small test quantities before large-scale purchases to evaluate product quality. For international shipments, ensure compliance with all relevant chemical transportation regulations. Establish long-term relationships with reputable suppliers to secure stable pricing and availability.
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