Vitamin K1
Overview
Vitamin K1 (Phylloquinone) is a naturally occurring fat-soluble vitamin primarily found in green leafy vegetables. As the primary form of Vitamin K in the diet, it plays a critical role in blood coagulation by serving as a cofactor for the synthesis of prothrombin and other clotting factors. First isolated in 1939 by Danish chemist Henrik Dam, Vitamin K1 is now produced synthetically for pharmaceutical and nutritional applications. Its molecular structure features a naphthoquinone ring with a phytyl side chain, distinguishing it from Vitamin K2 (menaquinones).
Physical and Chemical Properties
Vitamin K1 appears as a yellow to amber viscous liquid at room temperature, with a characteristic faint odor. It demonstrates stability against heat but is sensitive to light and alkaline conditions, requiring protection from UV radiation during storage. The compound's lipophilic nature dictates its solubility profile - readily dissolving in fats, oils, and organic solvents like ethanol or ether, while being practically insoluble in water. This property influences its absorption kinetics in the body, requiring bile salts for optimal intestinal uptake.
Main Applications
In pharmaceuticals, Vitamin K1 is principally used to reverse the effects of anticoagulant overdose (e.g., warfarin toxicity) and treat bleeding disorders. Injectable formulations are standard in hospital emergency protocols. The food industry employs Vitamin K1 as a nutritional fortifier in infant formula, dairy products, and dietary supplements. In agriculture, it's added to poultry and swine feed to prevent hemorrhagic disease and improve bone health. Emerging research explores its potential in cardiovascular and bone health applications.
Safety and Storage
Vitamin K1 has low acute toxicity (LD50 >5000 mg/kg in rats) but requires careful handling due to photosensitivity. Commercial products often contain antioxidants like tocopherol to prevent degradation. Proper storage mandates amber glass containers or foil-wrapped packaging under inert gas (nitrogen) at 2-8°C. Bulk shipments should use temperature-controlled logistics to maintain stability. Shelf life typically ranges 24-36 months when stored correctly.
B2B Procurement Guide
Pharmaceutical buyers should prioritize suppliers with GMP certification and compliance with USP/EP/JP monographs. Food-grade material requires FSSC 22000 or equivalent certification. Technical specifications should include: purity ≥98%, peroxide value <5 mEq/kg, and heavy metal limits. For international shipments, verify import regulations as some countries classify Vitamin K1 as a controlled substance. Sample testing for isomer purity (trans-content ≥98%) is recommended before large orders.
Related Manufacturers
- 主营：施耐德断路器接触器、ABB断路器接触器、ABB变频器、AB罗克韦尔模块、施耐德、西门子、三菱、常熟、欧姆龙、AB罗克韦尔、塑壳断路器、小型断路器、交流接触器、双电源开关、继电器、变频器、PLC模块、触摸屏、接近开关
- 主营：接线盒、防水接线盒、组合式配电箱、UL认证接线盒、UL接线盒、UL配电箱、聚碳酸酯配电箱、铸铝接线盒、IP68接线盒、IP65接线盒、Ml组合式配电箱、防火接线盒、不锈钢接线盒、防爆接线盒、UL认证铸铝接线盒
- 主营：塑胶颗粒、汽车材料、改性pp塑料颗粒、高密度塑胶原料、耐高温塑料、透明原料、弹性体塑料
- 主营：针式水听器、肺波形发生器、低氧发生器、分辨率测试卡、超声功率计、电子密度模体、.腹部模体、全身模体、躯干模体、乳腺模体、头部模体、CT性能模体、核磁共振模体、辐射力天平、X射线分析仪、霍夫曼脑模体、骨密度模体、肺结节模体、多普勒血流模体、SPECT性能模体、等中心校准模体、女性盆腔模体、胎儿超声模体、温升体模、扩散成像模体
- 主营：剂量仪、水听器、测试卡、WEK57、电导率表、散射校正板、压力传感器、超声功率计、声压传感器、细胞外放大器、散射校正模体、3500差分放大器、1800交流放大器、2mw分辨率瓦特表、高压绝缘测试仪、低氧发生器
- 主营：芳纶纤、碳纤维、铁氟龙、57、玻璃纤、高粘pa66、填充尼龙、薄壁产品、聚酰亚胺、聚苯硫醚、玻纤增强、导热塑料、二硫化钼、磁性尼龙、无人机零件、塑料添加剂、特氟龙微粉、高压开关壳体、半芳香族尼龙
- 主营：tps2062cd、tps2056ad、qpb3321sr、tps2057dr、tga2573-2、tps2091dr、qpb8888sr、tps2114pw、tps2044ad、tps2055ad、tps2115pw、tps2022dr、tps2021dr、tps2043dr、qpb2318sr、tps2066dr、qpb3311sr、tps2062ad、tps2095dr、tps2067dr、tps2087dr、tps2013ad、tps2046dr、tps2058ad、tps2010ad
- 主营：PMMA、PVC、TPE、57WK2001、TPU、PCT、PC、PPS、PP、PBT、POM、PC/ABS、MABS、CAP、CAB、PPO、TPV、CA、PCTG、PA66、PA6、PA6T、PA9T、PET
- 主营：蛇形弹簧、弹簧联轴器
- 主营：定香剂、氧化铅、浮选油、氧化铋、氟化铝、氟化镁、洗涤剂、异丙醇、漂粉精、漂白粉、白僵菌、乙酸钡、氟化钙、水杨酸、松醇油、碳酸钡、醋酸钡、95福美钠、苯丙乳液、三乙二醇、鱼虾养殖、单乙醇胺、三乙醇胺、氯偏乳液、快干水泥
- 主营：优氯净、甘氨酸、磷酸硼、水杨酸、硫酸锰、苯甲醇、平平加、正辛烷、一乙胺、磷酸氢、白僵菌、蛋白胨、碳酸镁、磷酸铝、异丁酸、叔丁醇、硫化钡、木质素、醋酸钡、硫化钙、氯化锌、黄原胶、磺酸钙、氟化镁、异丙醇
- 主营：德国施乐百风机、EBMPAPST风机、风电塔专用风机、57、空调散热风扇、表冷器散热风扇、静音风扇、汽车散热风扇、风机节能改造、锂电池散热风扇、储能散热风机、德国洛森风机、施依洛风机、亿利达风机、英飞风机、泛仕达风机、阀门定位器、三菱伺服驱动器、三菱以太网模块、三菱PLC模块、三菱CPU模块、三菱主基板、三菱伺服放大器、三菱控制器、三菱触摸屏、三菱定位模块
- 主营：水囊、油囊、沼气池、储气袋、吊重水袋、集雨水窖、浮力桶、红泥软体沼气池、打捞浮力桶、沼气柜、tpu水囊、电泳拼装罐、搪瓷拼装罐、黑膜沼气池、折叠水囊、消防水罐、桥梁预压水囊、储水袋、枕形浮力袋、折叠车载储油囊
- 主营：轴流风机、ebmpapst、施乐百、57、wistro、离心风机、防爆风机、DELTA风扇、SUNON风扇、Sanyo风扇、储能风扇、AHU风机、FFU风机、空调箱风机、制冷风机、冷凝器风机、农牧风机、轴流风扇、EC风机、充电桩风机、新能源风机
- 主营：液体密闭采样器、气体密闭取样器、聚四氟密闭取样器、氢氟酸取样器、回流比、气液平衡釜、转盘萃取塔