Overview
5-Methyluridine (m5U) is a naturally occurring modified nucleoside where a methyl group is added to the uracil base at the 5-position. It plays roles in RNA modification and is studied for its biological functions. As a research chemical, it is synthesized for applications in studying RNA metabolism, epigenetic modifications, and as a building block for oligonucleotide synthesis. Its stability and solubility make it suitable for laboratory use.
Physical and Chemical Properties
5-Methyluridine is a white crystalline powder with a molecular weight of 258.23 g/mol. It is soluble in water and dimethyl sulfoxide (DMSO), facilitating its use in aqueous and organic solutions. The compound exhibits a melting point of 185-190°C, indicating moderate thermal stability. Its UV absorption spectrum is typical for pyrimidine nucleosides, with a peak around 260 nm, useful for quantification in experiments.
Main Applications
In biochemistry, 5-methyluridine is used to investigate RNA modifications, particularly in tRNA and rRNA, where it influences stability and translational accuracy. Pharmaceutical research employs it to develop nucleoside analogs for antiviral or anticancer therapies. It also serves as a reference standard in analytical chemistry to validate methods for detecting modified nucleosides in biological samples.
Safety and Storage
While 5-methyluridine is not highly toxic, standard laboratory precautions are advised: use gloves, avoid inhalation, and work in a fume hood if handling powders. For long-term stability, store the compound at -20°C in a tightly sealed container, protected from light and moisture. Shelf life typically exceeds two years under these conditions.
B2B Procurement Guide
Buyers should prioritize suppliers providing certificates of analysis (CoA) with HPLC purity ≥98% and detailed spectroscopic data (NMR, MS). Bulk purchases (grams to kilograms) may qualify for discounts, but confirm batch consistency. Specialty chemical distributors or direct manufacturers are preferred for high-purity research-grade material.
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