Overview
5-Methoxy-1H-indole is an organic compound belonging to the indole family, characterized by a methoxy group at the 5-position of the indole ring. It is widely used as a building block in the synthesis of more complex molecules, particularly in pharmaceutical and agrochemical research. The compound's structure makes it a valuable intermediate for creating derivatives with potential biological activity. Indole derivatives are known for their presence in natural products and pharmaceuticals, and 5-Methoxy-1H-indole is no exception. Its applications span from academic research to industrial-scale synthesis, making it a compound of interest for chemists and manufacturers alike.
Physical and Chemical Properties
5-Methoxy-1H-indole appears as an off-white to pale yellow crystalline powder with a melting point range of 52-56°C. It is soluble in common organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO), but has limited solubility in water. The presence of the methoxy group influences its reactivity, making it a versatile intermediate for further chemical modifications. The compound's molecular weight is 147.17 g/mol, and its stability under normal conditions makes it suitable for storage and handling in laboratory and industrial settings. However, it should be protected from prolonged exposure to light and moisture to prevent degradation.
Main Applications
5-Methoxy-1H-indole is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Its indole core is a common motif in bioactive molecules, and the methoxy group can be further functionalized to create derivatives with specific properties. For example, it may serve as a precursor in the synthesis of serotonin analogs or other neurologically active compounds. In addition to pharmaceutical applications, this compound is also employed in academic research for studying indole chemistry and developing new synthetic methodologies. Its versatility and relatively straightforward synthesis make it a popular choice for chemists working in medicinal and organic chemistry.
Safety and Storage
When handling 5-Methoxy-1H-indole, appropriate safety measures should be taken to minimize exposure. This includes wearing gloves, goggles, and lab coats to avoid skin and eye contact. The compound should be used in a well-ventilated area or under a fume hood to prevent inhalation of dust or vapors. Storage conditions are critical to maintaining the compound's integrity. It should be kept in a tightly sealed container, away from light, heat, and moisture. Long-term storage at low temperatures (e.g., in a refrigerator) may be recommended for some applications, though this depends on the specific use case and supplier guidelines.
B2B Procurement Guide
For B2B buyers, sourcing 5-Methoxy-1H-indole requires attention to purity, supplier reliability, and cost. High-purity grades (e.g., ≥98%) are typically preferred for pharmaceutical and research applications, while lower grades may suffice for industrial uses. Buyers should request certificates of analysis (CoA) to verify purity and other specifications. Bulk purchases often come with discounted pricing, but it's essential to balance cost savings with storage capabilities and shelf life. Establishing relationships with reputable suppliers can ensure consistent quality and timely delivery. Additionally, buyers should stay informed about regulatory requirements, especially if the compound is used in regulated industries like pharmaceuticals.
Related Manufacturers
- 主营：甲氧基苯基、对照品、标准品
- 主营：聚苯胺、脯氨酸甲酯盐酸盐、苄基三甲基氯化铵
- 主营：石油醚、四氢噻吩、顺酐、苯酐
- 主营：化学试剂、氯金酸、卡尔费休、75、乙醇、异丙醇、药用辅料、依地酸钙钠、碳酸钠、盐酸氨丁三醇、龙胆酸、枸橼酸钠、甲醇、氢氧化钠、钴锰催化剂、硫酸锰、乙腈、色谱试剂、助剂、指示剂、醋酸锰、醋酸钴、氨丁三醇、尿素、硼酸
- 主营：无氟防水剂、碳六防水剂、防水剂、水性防水剂、油性防水剂、C6防水剂、C8防水剂、C0防水剂、碳八防水剂、防水助剂、防水整理剂、开油水、稀释剂、清洗剂、天那水、洗网水、防虹吸、防泼水、动态防水、除油剂、除锈剂、飞织防水、网布防水、鞋面防水
- 主营：杜仲素、对位酯、丙烯酸酯、二氧化硫脲、乙基麦芽酚、饲料添加剂、油酸基硬脂酸、二苯基硅二醇
- 主营：葛根提取物、姜黄素、羊奶粉、β-胡萝卜素、鱼油、蝶豆花粉、魔芋精粉、牦牛骨肽、蓝莓粉、胶原三肽、破壁松花粉、藤黄果提取物、椰子油粉、甘草酸二钾、亚麻籽油微囊粉、叶黄素、槲皮素、葛根黄酮、苯乙基间苯二酚、光甘草定、蓝莓花青素、中链甘油三酯、共轭亚油酸粉、玉米肽、沙棘冻干粉
- 主营：十一烯酸锌、周位酸、敌草隆、158474-72、鱼藤酮、对叔戊基苯酚、二醋酸纤维素、大茴香酸钠、肉豆蔻酸甲酯
- 主营：侧柏叶油、当归提取物、益智仁精油、甲氧基色胺、羟丙基硅油、侧柏叶精油、茴香提取液、墨旱莲提取物、接骨木提取液
- 主营：无水乙醇、乙酸乙酯、磷酸、甲氧基萘满酮、甲醇、乙二醇、二氯甲烷、异丙醇、二甲苯、各种化学试剂、化工原料
- 主营：生物素修饰蛋白、fitc标记蛋白、聚苯乙烯微球、16841、pvc微球、嵌段共聚物、生物素标记、荧光标记、纳米颗粒、核苷糖、aie、复合微球、功能化载玻片、荧光染料、金属配合物、Mxene、介孔二氧化硅微球、磁性纳米颗粒、小分子PEG、聚合物、纳米金、聚合物微球、荧光微球、荧光探针、点击化学、小分子
- 主营：生物缓冲剂、苯甲酸系列、农药、合成中间体
- 主营：甘氨酸、海藻糖、钙钛矿、2-[[(3ar、2-氯烟酸、氟苯基、油胺碘、硅酸锆、甘油醚、青霉素、状结晶、酒石酸、抗氧剂、钛白粉、凉味剂、晶粉末、硫酸钯、苯乙酮、白色粉、中间体、山梨醇、淡奶油、聚氯乙烯、清澈液体、白色细粉
- 主营：亚索化学试剂、化学试剂、生物试剂、检测试剂、化学色谱纯试剂、光谱纯试剂、分析纯AR试剂、优级纯GR试剂、基准试剂、高纯电子级试剂、标准化学试剂、滴定分析试剂、实验室试剂、通用试剂
- 主营：柠檬酸、蛋白酶k、卡波姆940、卡波姆941、卡波姆1342、羟乙基脲、邻香兰素、百里香酚、二甲苯青ff、异硫氰酸胍、醋酸氯己定、醋酸洗必泰、甘草酸二钾、甘宝素、二苯基二羟基硅烷