Overview
5-Hydroxyindole is a heterocyclic aromatic organic compound, structurally related to indole with a hydroxyl group at the 5-position. It is a versatile intermediate in medicinal chemistry, notably in the synthesis of serotonin (5-hydroxytryptamine) and related compounds. The CAS registry number 530-8-25 uniquely identifies this compound for regulatory and procurement purposes. Industrial production typically involves catalytic hydroxylation of indole or multi-step organic synthesis. Its significance in neuroscience and drug development has driven demand among pharmaceutical manufacturers and research institutions.
Physical and Chemical Properties
As a crystalline solid, 5-hydroxyindole exhibits moderate stability under standard conditions but may degrade upon prolonged exposure to air or light. Its solubility profile favors polar organic solvents, making it suitable for laboratory-scale reactions. The compound's melting point range (140-145°C) serves as a key purity indicator during quality control. The presence of both indole and phenolic functional groups grants unique reactivity: the hydroxyl group participates in etherification or esterification, while the nitrogen-containing ring enables electrophilic substitutions. These properties make it valuable for designing serotonin analogs and other bioactive molecules.
Main Applications
In pharmaceuticals, 5-hydroxyindole is primarily used to synthesize serotonin pathway modulators, including antidepressants and migraine medications. It also serves as a scaffold for developing radiolabeled tracers in PET imaging studies of neurological disorders. The biochemical sector employs it as a standard for HPLC calibration in neurotransmitter analysis. Emerging applications include organic electronics, where its conjugated structure contributes to charge transport in specialty materials. Research-grade quantities are essential for studying tryptophan metabolism pathways in academic and industrial labs.
Safety and Storage
While not classified as highly hazardous, 5-hydroxyindole requires careful handling due to potential irritation to skin, eyes, and respiratory system. Laboratory safety protocols mandate fume hood use and personal protective equipment (PPE) including nitrile gloves and safety goggles. Long-term storage recommendations include amber glass containers with airtight seals, preferably under nitrogen atmosphere to prevent oxidation. Stability tests indicate shelf life of 2-3 years when stored at 2-8°C. Material Safety Data Sheets (MSDS) should be consulted for spill response and disposal procedures compliant with local regulations.
B2B Procurement Guide
Bulk purchasers should prioritize suppliers with documented quality control processes, including batch-specific Certificate of Analysis (CoA) showing purity (typically ≥98% by HPLC), residual solvent levels, and heavy metal content. Technical specifications often include particle size distribution for formulation compatibility. For GMP-compliant pharmaceutical applications, audit supplier facilities for ISO 9001 or equivalent certifications. Just-in-time delivery options minimize storage risks. Spot prices fluctuate based on raw material (indole derivatives) availability; contract manufacturing agreements may offer cost advantages for multi-kilogram orders.
Related Manufacturers
- 主营：530、innovatek
- 主营：micronext、分析仪、interpump、336973-74、521-10-30、s-15-08-n、发电机、光栅尺、保护管、zetasassi、制动器、x20ai1744、连接器、vib5.756i、压力机、分流器、电感器、电动机、护目镜、电化学、变流器、计数器、beyerotto、rodriguez、离合器
- 主营：幻灯机
- 主营：探测器、压铆枪、齿轮泵、hmsab7000-c、exsysex-11053、打印机、照度计、过滤器、制动器、传感器、编码器、流量计、继电器、电容器、冷却器、控制器、中继器、磁场计、htrf8p0150rj、分析仪led、旋转接头、通信模块、接口模块、preeflow20426、vishaynobelwst3
- 主营：gt030h060、冷冻柜、摸模块、cap-net-c、1-scout55、p-6035/10、bc-600-pb、诊断仪、抛光膏、分析仪、csw配件、隔膜泵、催化剂、中继器、wing/bsol、气动阀、摄像头、编码器、电磁阀、测量仪、温控仪、膜厚计、光纤头、止回阀、金属胶
- 主营：530、输送机
- 主营：pic16f914、pic16f916、pic16f917、msp40-gdr、pic-15/55、pic16f684、pic16f685、pic16f687、pic16f683、封装bga、mic809tuy、pic16f785、pic16f527、pic16f526、pic16c55a、pic10f206、pic10f202、pic10f200、pic16f883、pic16f886、pic16f887、pic16c54c、mt2601w/a、pic12f629、pic18f24k
- 主营：汽车底盘听诊器、高速脱水机、水分测试仪、震动传感器、钣金修复机、皮肤采样盘