5-Hydroxy-2-pentanone

Updated: 2026-07-15

Overview

5-Hydroxy-2-pentanone, also known as 3-acetylpropanol, is an organic compound with the molecular formula C5H10O2. It is a colorless to pale yellow liquid with a mild odor and is soluble in water and most organic solvents. This compound is primarily used as an intermediate in the synthesis of pharmaceuticals and flavoring agents. Its versatility in chemical reactions makes it valuable in various industrial applications. 5-Hydroxy-2-pentanone is hygroscopic, meaning it readily absorbs moisture from the environment. This property necessitates careful storage to maintain its stability and effectiveness. The compound is typically stored in tightly sealed containers to prevent degradation and contamination.

Physical and Chemical Properties

5-Hydroxy-2-pentanone has a molecular weight of 102.13 g/mol and a density of approximately 0.96 g/cm³ at 20°C. It boils at around 215-217°C and is soluble in water and most organic solvents, including ethanol and acetone. The compound's mild odor and hygroscopic nature are key characteristics that influence its handling and storage requirements. The chemical structure of 5-hydroxy-2-pentanone includes both a hydroxyl group and a ketone functional group, making it reactive in various chemical processes. This dual functionality allows it to participate in reactions such as esterification and condensation, which are common in pharmaceutical and flavor synthesis.

Main Applications

5-Hydroxy-2-pentanone is widely used as an intermediate in the pharmaceutical industry, where it serves as a building block for the synthesis of active pharmaceutical ingredients (APIs). Its role in flavoring agents is also significant, as it contributes to the creation of fruity and sweet aromas in food products. Additionally, the compound is utilized in organic synthesis for producing various specialty chemicals. In the agrochemical sector, 5-hydroxy-2-pentanone is employed in the development of pesticides and herbicides. Its reactivity and solubility make it a versatile component in formulating effective agricultural chemicals. The compound's applications extend to the cosmetics industry, where it is used in fragrances and skincare products.

Safety and Storage

Handling 5-hydroxy-2-pentanone requires caution due to its potential to cause skin and eye irritation. Personal protective equipment (PPE), such as gloves and safety goggles, should be worn when working with this chemical. Adequate ventilation is essential to prevent inhalation of vapors, which may cause respiratory discomfort. Storage conditions for 5-hydroxy-2-pentanone include keeping the compound in a cool, dry, and well-ventilated area away from heat sources and open flames. Containers should be tightly sealed to prevent moisture absorption and contamination. Proper labeling and segregation from incompatible substances, such as strong oxidizing agents, are critical for safe storage.

B2B Procurement Guide

When procuring 5-hydroxy-2-pentanone, it is essential to verify the supplier's credibility and the quality of the product. Request a Certificate of Analysis (CoA) to confirm the compound's purity and compliance with industry standards. Bulk purchases may offer cost advantages, but ensure that storage facilities meet the necessary safety requirements. Consider the logistics of transportation, especially for large quantities. The compound should be shipped in secure, leak-proof containers to prevent spills and exposure. Establishing a long-term relationship with a reliable supplier can ensure consistent quality and timely delivery, which is crucial for industrial applications.