Overview
5-Bromothiazole is a brominated derivative of thiazole, a five-membered heterocyclic compound containing sulfur and nitrogen. It serves as a versatile intermediate in organic synthesis, particularly in the pharmaceutical and agrochemical industries. The compound's reactive bromine atom allows for further functionalization via cross-coupling reactions, making it valuable for constructing complex molecules. Its thiazole core is a privileged structure in medicinal chemistry, contributing to bioactive properties in many drugs.
Physical and Chemical Properties
As a liquid at room temperature, 5-bromothiazole exhibits moderate volatility with a distinct aromatic odor. Its density of 1.81 g/cm³ indicates it is heavier than water. The bromine atom significantly influences its reactivity, enabling nucleophilic substitutions and metal-catalyzed couplings. The compound's solubility profile makes it compatible with common organic solvents, though its limited water solubility requires careful handling in aqueous systems. Its stability is generally good when stored properly, but decomposition may occur under prolonged exposure to light or moisture.
Main Applications
In pharmaceuticals, 5-bromothiazole is employed as a building block for antiviral, antibacterial, and anticancer agents. The thiazole moiety appears in numerous FDA-approved drugs, with bromination allowing precise molecular modifications. Agrochemical applications include its use in synthesizing fungicides and herbicides, where the bromothiazole structure contributes to biological activity. Additionally, it serves in material science for creating conductive polymers and liquid crystals with tailored electronic properties.
Safety and Storage
Proper handling requires chemical-resistant gloves, goggles, and fume control due to potential skin/eye irritation and respiratory sensitization. Secondary containment is recommended for bulk storage to prevent environmental release. For long-term stability, store under inert atmosphere (argon/nitrogen) at 2-8°C in amber glass containers. Shelf life typically exceeds 24 months when protected from moisture and oxygen. Incompatible materials include strong bases and oxidizing agents.
B2B Procurement Guide
When sourcing 5-bromothiazole, prioritize suppliers with ISO-certified production facilities and analytical documentation (HPLC/GC purity reports). Batch-to-batch consistency is critical for industrial applications. Consider minimum order quantities (MOQs) and lead times—custom synthesis may require 4-8 weeks. For international shipments, verify compliance with transportation regulations for brominated compounds. Some manufacturers offer toll manufacturing services for derivative synthesis.
Related Manufacturers
- 主营：聚苯胺、脯氨酸甲酯盐酸盐、苄基三甲基氯化铵
- 主营：环戊酮、甲酸镍、阻燃剂、溴噻唑、草酸镧、钼酸铵、催化剂、钒酸铋、溴氨酸、硝酸锆、碳酸镧、白僵菌、磷酸铁、钨酸酐、氟化镧、视黄醇、叔丁醇、杀螨剂、杀虫剂、醋酸钬、抗粘剂、氟化镥、肟菌酯、氢化钠、氯铂酸、氟化镁
- 主营：乙二醇、二甲基亚砜、丙二醇、4-丁二醇、精对苯二甲酸、己二酸、聚乙烯醇、聚乙二醇、木质素、甘油、三甘醇、己内酰胺、叔十二硫醇、白油、对苯二甲酸二甲酯
- 主营：溴噻唑、精细化工品、润滑油、有机中间体
- 主营：聚乙烯胺、化学试剂、分析试剂、溴噻唑、通用试剂、生化试剂
- 主营：乙醛酸、铁甲酸、二甲基、3-氯丙炔、3-氯水扬酸、2-羟基喹喔啉、2-苯并唑啉酮、3-环戊二羧酸、6-二氯异烟酸、2-氨基-5-氯苯酚、羟乙基、草酰胺、邻苯二甲、苯甲酰胺、溴氯海因、磷酸三甲酯、对羟基苯海因
- 主营：杂环化合物、丙烯酸系列
- 主营：顺-6-壬烯-1-醇
- 主营：甘氨酰、二苯胍、碳酸镁、55、特戊醛、化合物、碲化钠
- 主营：恩布酯、甘氨酰、二苯胺、4282-24-0、1692-15-5、7779-90-0、1897-45-6、6809-52-5、7681-52-9、3486-30-4、1776-30-3、5856-62-2、1317-80-2、1069-23-4、聚合物、嘧菌酯、磷酸铬、褪黑素、吡咯基、达比加、异戊醛、化合物、氟苯基、碲化钠、氟洛芬
- 主营：三硫代碳酸钠、聚乙烯亚胺、三乙二醇二异辛酸酯、红色素-16、L-丙交酯、石油酯-T50、巯基苯并噻唑钠、乙交酯、多元醇苯甲酸酯、热压敏染料、光稳定剂、高分子降解材料
- 主营：二甲基亚砜、乙二醇、丙二醇、溴噻唑氢溴酸盐、DMAC
- 主营：环己基苯、乙基纤维素、硫酸烟酰苯胺、5-二甲基吡唑、N-油酰基肌氨酸、β-溴苯乙烷、2-辛烯基琥珀酸酐、5二硝基水杨酸、菜籽油甲酯、辛酸镁、辛酸钾、有机硅季铵盐、萘钠处理液
- 主营：聚乙烯胺、烯丙基磺酸钠、分析标准品、糖精钠 128-44-9、70693-62-8 过硫酸氢钾、水杨酸钠 54-21-7、硫化钴 12013-10-4、催化剂及助剂
- 主营：异丙醇、二甲胺、二甲苯、溴噻唑氢溴酸盐、苯基氯、二甘醇、石炭酸、乙二醇、丙烯酸、仲丁醇、水溶液、羟基苯、红铅丹、氨基苯、安息油、环己醇、正丁醇、84消毒液、单乙醇胺、医用酒精、液状石蜡、邻甲苯胺、杀菌消毒、乙基三胺、出口酒精、乙烯基苯