Overview
5-Bromoindanone is a brominated derivative of indanone, a cyclic ketone with a five-membered ring structure. It is primarily used as an intermediate in organic synthesis, particularly in the pharmaceutical industry for the production of bioactive compounds. The bromine substituent enhances its reactivity, making it valuable for further chemical modifications. This compound is typically synthesized through bromination reactions of indanone derivatives. Its role as a building block in medicinal chemistry underscores its importance in drug discovery and development processes.
Physical and Chemical Properties
5-Bromoindanone appears as a pale yellow to white crystalline powder with a molecular weight of 211.06 g/mol. It is soluble in common organic solvents such as ethanol, acetone, and dimethyl sulfoxide (DMSO), but has limited solubility in water. The compound exhibits stability under standard conditions but may degrade upon prolonged exposure to light or moisture. Its melting point ranges between 80-85°C, which is a critical parameter for handling and storage. The bromine atom attached to the aromatic ring significantly influences its electronic properties, making it a versatile reagent in electrophilic substitution reactions.
Main Applications
The primary use of 5-Bromoindanone is as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It serves as a precursor for various biologically active molecules, including antipsychotic and anti-inflammatory agents. Researchers also employ it in the development of novel organic compounds with potential therapeutic effects. In addition to pharmaceuticals, this compound finds applications in material science, where it is used to modify polymer properties or create specialized coatings. Its reactivity makes it a valuable tool in academic and industrial research laboratories.
Safety and Storage
5-Bromoindanone should be handled with care, as it may cause skin and eye irritation upon contact. Proper personal protective equipment (PPE), including gloves and goggles, is recommended when working with this chemical. Adequate ventilation is essential to avoid inhalation of dust or vapors. Storage conditions should prioritize a cool, dry environment, away from direct sunlight and moisture. The compound should be kept in a tightly sealed container to prevent degradation. Compliance with local chemical safety regulations is mandatory for industrial and laboratory use.
B2B Procurement Guide
When procuring 5-Bromoindanone, businesses should prioritize suppliers with a proven track record of quality and reliability. Key considerations include verifying the compound's purity through certificates of analysis (CoA) and ensuring compliance with international safety standards such as REACH or GHS. Bulk purchases may offer cost advantages, but storage capacity and shelf-life should be evaluated. Requesting material safety data sheets (MSDS) is essential for risk assessment and regulatory compliance. Establishing long-term partnerships with reputable suppliers can ensure consistent quality and timely delivery.
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