Overview
5α-Androstanedione is a steroid hormone intermediate derived from androstenedione via 5α-reductase. It plays a role in the biosynthesis of dihydrotestosterone (DHT) and other androgens. As a key metabolite in steroid pathways, it is widely used in pharmaceutical research and development. This compound is primarily synthesized for laboratory and industrial applications, particularly in studies related to endocrine function, hormone-dependent cancers, and metabolic disorders. Its stability and specificity make it valuable for controlled biochemical experiments.
Physical and Chemical Properties
5α-Androstanedione is a white crystalline powder with a molecular weight of 288.43 g/mol. It is soluble in organic solvents like ethanol and dimethyl sulfoxide (DMSO) but insoluble in water due to its hydrophobic steroid backbone. The melting point ranges between 170-175°C, typical for similar steroid compounds. Under standard conditions, it is stable but sensitive to prolonged exposure to light, heat, or moisture. Proper storage in airtight containers with desiccants is recommended to maintain purity. Analytical methods such as HPLC and GC-MS are commonly used to verify its identity and concentration.
Main Applications
In pharmaceuticals, 5α-Androstanedione serves as a precursor in the synthesis of DHT and related androgen receptor modulators. It is also used to study hormone metabolism, particularly in conditions like benign prostatic hyperplasia (BPH) and androgenetic alopecia. Research laboratories employ this compound to investigate enzyme kinetics (e.g., 5α-reductase activity) and to develop assays for steroidogenic pathways. Its role in endocrine-disrupting chemical studies further underscores its relevance in environmental and toxicological research.
Safety and Storage
While not classified as highly hazardous, 5α-Androstanedione requires careful handling to avoid inhalation or skin contact. Use nitrile gloves, lab coats, and safety goggles in workplaces. Spills should be contained with absorbent materials and disposed of as hazardous waste. Long-term storage demands temperature control (2-8°C) and protection from light. Amber glass vials with tight seals are ideal. Stability tests indicate minimal degradation under these conditions for up to two years, though periodic purity checks are advised for critical applications.
B2B Procurement Guide
When sourcing 5α-Androstanedione, prioritize suppliers with documented quality control processes and certifications (e.g., ISO 9001). Request certificates of analysis (CoA) specifying purity (≥98%), residual solvents, and heavy metal content. Bulk purchases (100g+) may qualify for discounts, but confirm lead times and shipping conditions (e.g., cold chain for international orders). Compare prices from specialized chemical distributors and negotiate batch testing for consistency. For research-grade material, opt for suppliers with peer-reviewed product references.
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