4-Pyridinecarboxaldehyde[2]

Updated: 2026-09-12

Overview

4-Pyridinecarboxaldehyde, also known as 4-formylpyridine, is an organic compound with the formula C6H5NO. It is a derivative of pyridine and is widely used in the synthesis of pharmaceuticals and agrochemicals. The compound is a colorless to pale yellow liquid with a characteristic aldehyde odor. Its reactivity makes it a valuable intermediate in organic chemistry. 4-Pyridinecarboxaldehyde is primarily used in the pharmaceutical industry for the synthesis of various drugs and active pharmaceutical ingredients (APIs). It is also employed in the production of agrochemicals and specialty chemicals. The compound's versatility and reactivity make it a key building block in many synthetic pathways.

Physical and Chemical Properties

4-Pyridinecarboxaldehyde is a liquid at room temperature with a density of 1.13 g/cm³. It has a boiling point of 180-182 °C and is soluble in water and most organic solvents, including ethanol, methanol, and acetone. The compound is highly reactive due to the presence of both a pyridine ring and an aldehyde functional group. The aldehyde group in 4-Pyridinecarboxaldehyde makes it susceptible to nucleophilic addition reactions, while the pyridine ring can participate in various substitution reactions. These properties make it a versatile reagent in organic synthesis. The compound should be handled with care due to its irritant properties and potential to cause skin and eye irritation.

Main Applications

4-Pyridinecarboxaldehyde is predominantly used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It is a key building block in the production of antihistamines, antiviral agents, and other therapeutic compounds. The compound's reactivity allows for the introduction of the pyridine moiety into more complex molecules. In addition to pharmaceuticals, 4-Pyridinecarboxaldehyde is used in the agrochemical industry for the synthesis of pesticides and herbicides. It is also employed in the production of specialty chemicals, including dyes and fragrances. The compound's versatility and ease of functionalization make it a valuable reagent in research and industrial applications.

Safety and Storage

4-Pyridinecarboxaldehyde is classified as an irritant and should be handled with appropriate personal protective equipment (PPE), including gloves, goggles, and lab coats. The compound should be stored in a cool, dry, well-ventilated area away from heat sources and open flames to prevent decomposition or combustion. In case of skin contact, wash immediately with plenty of water. For eye exposure, rinse thoroughly with water and seek medical attention if irritation persists. The compound should be kept in tightly sealed containers to prevent moisture absorption and degradation. Proper disposal methods should be followed to minimize environmental impact.

B2B Procurement Guide

When procuring 4-Pyridinecarboxaldehyde, it is essential to verify the supplier's credentials and ensure they provide certificates of analysis (CoA) and material safety data sheets (MSDS). The compound is typically available in various purity grades, with higher purity levels commanding a premium price. Bulk purchases may offer cost savings, but it is advisable to confirm storage and handling requirements before large-scale procurement. Buyers should also consider the supplier's logistics capabilities, including packaging and shipping options, to ensure the product arrives in optimal condition. Establishing a long-term relationship with a reliable supplier can help secure consistent quality and timely deliveries.