Overview
4-Phenylacetophenone (CAS 92-91-1) is an aromatic ketone derived from biphenyl, characterized by its acetyl functional group. It serves as a versatile intermediate in organic synthesis, particularly in pharmaceuticals and specialty chemicals. The compound's stability and reactivity make it valuable for constructing complex molecules. Industrially, it is synthesized via Friedel-Crafts acylation of biphenyl. Its crystalline form and moderate solubility in organic solvents facilitate handling in laboratory and production settings. Regulatory compliance (e.g., REACH) is essential for commercial use.
Physical and Chemical Properties
The compound appears as a white crystalline solid with a melting point of 119-122°C, indicating moderate thermal stability. Its density of ~1.09 g/cm³ and boiling point of ~323°C reflect typical aromatic ketone behavior. 4-Phenylacetophenone is insoluble in water but dissolves readily in ethanol, acetone, and ether. Its UV absorption properties (λmax ~250 nm) are exploited in analytical applications. The ketone group is reactive toward nucleophiles, enabling derivatization for targeted synthesis.
Main Applications
In pharmaceuticals, 4-phenylacetophenone is a precursor for anti-inflammatory and antiviral agents. Its biphenyl backbone is integral to active pharmaceutical ingredients (APIs). The fragrance industry utilizes it to synthesize musk analogs and floral scent components. Additionally, it acts as a photoinitiator in polymer chemistry and a ligand in catalytic systems. Niche uses include liquid crystal materials and agrochemical intermediates.
Safety and Storage
The compound is classified as hazardous upon prolonged exposure. Skin or eye contact may cause irritation; use nitrile gloves and safety goggles. Ensure adequate ventilation to avoid dust inhalation. Store in sealed containers under ambient conditions, segregated from strong oxidizers. Shelf life exceeds two years if stored properly. Dispose of waste per local regulations, avoiding environmental release.
B2B Procurement Guide
Procure 4-phenylacetophenone from suppliers with ISO 9001 certification to ensure quality consistency. Request COA (Certificate of Analysis) specifying purity (≥98%) and residual solvent levels. Bulk pricing tiers apply for orders above 100 kg. Consider incoterms (e.g., CIF, FOB) and lead times (typically 2-4 weeks). Sample testing is recommended before large-scale orders. Logistics should prioritize temperature-controlled transport for tropical climates.
Related Manufacturers
- 主营：异丙醇、二甲胺、二甲苯、苯基氯、84消毒液、二甘醇、石炭酸、乙二醇、丙烯酸、仲丁醇、水溶液、羟基苯、红铅丹、氨基苯、安息油、环己醇、正丁醇、单乙醇胺、医用酒精、液状石蜡、邻甲苯胺、杀菌消毒、乙基三胺、出口酒精、乙烯基苯
- 主营：防冻液、冰醋酸、乙二醇、14丁二醇、3-丙三醇、1.4丁二醇、冰乙酸、纯吡啶、丙二醇、羟基苯、四氢呋喃、环保乙腈、化工苯酚、医用苯酚、工业苯酚、精制苯酚、价位四氢、乙腈工业、乙酸乙酯、吡啶化工、甲酸乙酯、吡啶工业、求购苯酚、高纯三氯、实验乙腈
- 主营：五金工件、涂料油墨、化工原料、苯乙酮、医药中间体、航空煤油、二价酸酯、乙二醇、丙烯酸丁酯、二氯甲烷、环己酮、食用酒精
- 主营：二甲基亚砜、乙二醇、丙二醇、苯基苯乙酮、DMAC
- 主营：肌氨酸钠、硫化锰、V50偶氮二异丁脒盐酸盐、PX-4MP、腰果酚缩水甘油醚、乙硫氮、二新癸酸二甲基锡、三硫代碳酸钠、芥酸PKO、四氧化三锰
- 主营：杜仲素、对位酯、丙烯酸酯、二苯基硅二醇、二氧化硫脲、乙基麦芽酚、饲料添加剂、油酸基硬脂酸
- 主营：山梨酸钾、羟基嘧啶、吡唑啉酮、磺酸苯基、甲基苯基、清凉茶酸、山梨酸钙、叔丁基锂、双乙烯酮、基氨基锂、氯乙酰氯、三正丁基、四羟甲基、乙酰苯胺、氯羟吡啶、硫酸磷脲
- 主营：植物醇、植物提取物、聚二羟基吲哚、8-二氨基萘、4-萘二甲酸、8-氨基喹哪啶、2-巯基噻唑啉、6-二羟基吲哚氢、4-辛氧基二苯碘六氟、DL-樟脑醌、4-羟乙基哌嗪乙磺酸、5-甲基 N-乙烯基、L-谷氨酸-5-叔丁、聚季铵盐-55、磷钼酸、石胆酸、乙烯基膦酸、劳伦酸、二水合钼酸钠、麦角硫因、羟乙基磺酸、钼酸、甲基丙烯酸氧杂环丁烷、三羟甲基氨基甲烷盐酸、腺苷
- 主营：表面活性剂、有机硅、光引发剂、联苯乙酮、抗氧剂、中间体、选矿药剂
- 主营：三甲基羟乙基乙二胺、五甲基二乙烯三胺、钛酸四丁酯、联苯乙酮、三氯叔丁醇、氨基钠、碳酸胍、降龙涎香醚、甲基丙烯酸纳、四溴双酚A、正辛基三乙氧基硅烷
- 主营：阻燃剂、乙酸镍、胶黏剂、苯乙酮、指示剂、棉织物、六溴苯、磷酸铁、肉桂醇、碳酸镁、麝香酮、肉桂醛、芹菜酮、异丁酸、乙氧基、四甘醇、衍生物、癸酸酯、浮选剂、稀释剂、羟乙基、异恶唑、马尿酸、十八烷、珠光剂、乙酸锶
- 主营：苯乙酮、萃取剂、选矿药剂、金矿硫化矿
- 主营：保水剂、酸度调节剂、表面活性剂、联苯乙酮、食品添加剂
- 主营：苯甲醛、酰亚胺、苯磺酸、cas-50-63-5、异丙基、氨基丙基、试剂医药、化学醋酸、化学试剂、甲基硅基、盐酸羟胺、苯并三唑、苄基丙酮、试剂化工、丙烯酰氯、甲基乙炔、氮杂苯并、二叔丁酯、磷酸二苯酯、化学碳酸钾、二酸二乙酯、酸二异丙酯、二咪唑羰基、中间体化工、医药中间体
- 主营：还原铁粉、中性防锈剂、一水硫酸锌、联苯乙酮厂家4、营养强化剂、杀菌防腐剂、油墨造纸助剂、顺丁烯二酸酐、工业级黄丹粉、杀菌剂防霉剂、金属零件防锈剂
- 主营：n-甲基吡咯烷酮、紫胶片、碳酸钠、氮杂双环