Overview
4-O-Methyllicochalcone is a flavonoid derivative isolated from licorice root (Glycyrrhiza species), a plant traditionally used in herbal medicine. It is structurally related to licochalcone A and B, with an additional methoxy group enhancing its stability and bioactivity. This compound has gained attention in pharmaceutical and cosmetic research due to its potential therapeutic properties, including antioxidant and anti-inflammatory effects. Its molecular structure allows it to interact with biological targets, making it a candidate for drug development and skincare formulations. In industrial settings, 4-O-Methyllicochalcone is typically supplied as a fine powder, requiring careful handling to maintain its integrity. Its applications span across multiple industries, including pharmaceuticals, where it is studied for its bioactive potential, and cosmetics, where it is valued for its skin-beneficial properties.
Physical and Chemical Properties
4-O-Methyllicochalcone is a yellow to pale brown crystalline powder with a molecular weight of 366.41 g/mol. It is soluble in organic solvents such as dimethyl sulfoxide (DMSO) and ethanol but has limited solubility in water. The compound exhibits a melting point range of approximately 150-155°C, which is indicative of its moderate thermal stability. Its chemical structure includes a chalcone backbone with a methoxy group at the 4-position, contributing to its unique reactivity and biological activity. The presence of conjugated double bonds in its structure is responsible for its antioxidant properties, as it can scavenge free radicals and reduce oxidative stress. These properties make it a valuable compound for research in oxidative stress-related diseases and anti-aging formulations.
Main Applications
4-O-Methyllicochalcone is primarily used in pharmaceutical research, where its anti-inflammatory and antimicrobial properties are investigated for potential therapeutic applications. Studies suggest it may inhibit enzymes involved in inflammatory pathways, making it a candidate for treating conditions like dermatitis or arthritis. Additionally, its antimicrobial activity against certain bacteria and fungi has sparked interest in developing novel antibiotics or preservatives. In the cosmetic industry, this compound is incorporated into skincare products for its antioxidant benefits, which help protect the skin from environmental damage and premature aging. It is also explored in nutraceuticals for its potential health-promoting effects. The compound's versatility and bioactive profile make it a valuable ingredient in multiple high-value applications.
Safety and Storage
4-O-Methyllicochalcone should be handled with caution to avoid inhalation or skin contact, as its biological activity may pose risks if mishandled. Personal protective equipment (PPE), including gloves and lab coats, is recommended during use. The compound should be stored in a cool, dry environment, away from direct light and moisture, to prevent degradation. Stability studies indicate that the compound remains stable under recommended storage conditions, but prolonged exposure to heat or humidity may affect its efficacy. Suppliers often provide certificates of analysis (CoA) detailing purity and storage guidelines, which should be reviewed before use. Proper disposal methods should be followed to minimize environmental impact.
B2B Procurement Guide
When procuring 4-O-Methyllicochalcone, B2B buyers should prioritize suppliers with a proven track record of quality and reliability. Key considerations include verifying the compound's purity (typically via HPLC or MS analysis) and ensuring compliance with industry standards such as ISO or GMP. Buyers should request detailed product specifications, including batch-specific data and safety documentation. Price varies depending on purity and quantity, with higher purity grades commanding premium prices. Bulk purchases may offer cost advantages, but buyers should assess storage capabilities to maintain product integrity. Establishing long-term relationships with reputable suppliers can ensure consistent quality and availability. Additionally, buyers should stay informed about regulatory changes affecting the compound's use in target industries.
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