Overview
4-Nitroanisole is an organic nitro compound derived from anisole, featuring a nitro group at the para position of the benzene ring. Its molecular structure (C7H7NO3) makes it valuable as a building block in synthetic chemistry. First synthesized in the late 19th century, this compound gained industrial significance during the expansion of synthetic dye production. The chemical's primary commercial value lies in its role as an intermediate, particularly in azo dye manufacturing where it contributes to chromophore development. Industrial production typically involves nitration of anisole under controlled conditions, yielding material with 98-99% purity for commercial applications.
Physical and Chemical Properties
As a crystalline solid, 4-nitroanisole displays characteristic yellow coloration and mild aromatic odor. Its melting point range of 51-54°C allows for easy handling in molten form during industrial processes. The compound demonstrates stability at room temperature but may decompose under prolonged exposure to strong light or elevated temperatures (>200°C). In terms of reactivity, the nitro group activates the benzene ring for electrophilic substitution while the methoxy group directs further reactions to specific positions. The compound shows good solubility in common organic solvents like ethanol (50 g/L at 20°C) and ether, but minimal water solubility (0.5 g/L), a factor influencing its environmental fate.
Main Applications
Approximately 70% of 4-nitroanisole production serves the dye industry, particularly in manufacturing yellow and orange azo dyes for textiles and plastics. These dyes benefit from the compound's ability to form stable diazonium salts during synthesis. The pharmaceutical sector utilizes it as a precursor for certain APIs, including some vasodilators and antimicrobial agents. Research laboratories employ 4-nitroanisole as a model compound for studying electrophilic aromatic substitution mechanisms. Emerging applications include use in liquid crystal intermediates and as a standard in chromatographic analysis. Specialty chemical manufacturers may further derivatize it to produce more complex nitro-aromatic compounds.
Safety and Storage
Proper handling requires PPE including nitrile gloves and safety goggles due to 4-nitroanisole's irritant properties. The compound is classified as harmful if swallowed (H302) and toxic to aquatic life (H411). Storage should occur in tightly sealed amber containers to prevent photodegradation, maintained at temperatures below 30°C in well-ventilated areas. Spill management involves containment with inert absorbents, avoiding methods that generate dust. Disposal must comply with local regulations for nitroaromatics, typically through licensed hazardous waste handlers. Firefighting requires alcohol-resistant foam due to the compound's combustible nature at high temperatures.
B2B Procurement Guide
Industrial buyers should specify purity requirements (technical grade typically 98%, reagent grade ≥99%) and packaging preferences (25kg fiber drums being most common). Lead times average 2-4 weeks for standard orders, with larger quantities (tonnage) sometimes available from stock. Quality verification should include certificates of analysis for melting point range and HPLC purity assays. Supply chain considerations include verifying supplier compliance with REACH regulations and transportation certifications. Some manufacturers offer custom synthesis for derivative products. Price fluctuations may occur with changes in raw material (anisole) costs, with annual contracts providing stability for regular purchasers.
Related Manufacturers
- 主营：传感器、流量计、电磁阀、气缸、继电器、液位开关、仪器仪表、开关电源、电机
- 主营：接近开关、传感器、编码器、光电开关、气缸、电磁阀
- 主营：PLC模块、控制器、继电器、4n、耦合器、安全模块、IO端子模块、bekomat13、bekomat30、bekomat31u、beko滤芯、EK1100、CX8090、电机端子、安全开关、数字输出、电源端子、BK3150、EL6751、EL6731、端子模块、EL1809、EL1889、EL2809、EL2889、EL9510
- 主营：进口油泵
- 主营：机械密封、执行器、导轨滑块、4n、轴承、电机、减速机、编码器、传感器、继电器
- 主营：西克传感器、易福门传感器、施耐德传感器、4n、巴鲁夫传感器、邦纳传感器
- 主营：德国雄克schunk、德国GRIP、德国zimmer、德国IPR、倍福Beckhoff、普尔世puls、REER(瑞奥)、德国多德dold、德国PULS普尔世
- 主营：德国DEHN防雷器、德国OBO防雷器、菲尼克斯防雷器、773536PNOZmo4p4n、法国CITEL防雷器、PHOENIX电涌保护器、辰竹信号隔离器、东土交换机
- 主营：齿轮泵、气动阀、减压器、4n、减速机、监视器、电磁阀、隔膜片、1756-l63b、方向阀、液压泵、放大器、溢流阀、进口阀、传感器、换向阀、调节阀、流量阀、流量计、反应阀、plc控制、调压阀、手动阀、计量泵、调温器、调节器
- 主营：威纶通触摸屏、西克sick传感器、施耐德接触器、4n、明纬电源、欧姆龙传感器、昆仑触摸屏、劳恩光栅光幕、ABB变频器、顾美一体机、西门子PLC、三菱PLC、松下传感器、之山伺服、博恩斯坦安全开关、海为PLC、汇辰PLC、亿维PLC、霍尼韦尔中间继电器、奥托尼克斯传感器、菲尼克斯接线端子、魏德米勒开关电源、德力西断路器、阳明固态继电器、明治传感器、基恩士传感器
- 主营：PZEX424VDC4n、变频器、风机水泵
- 主营：控制器、变频器、伺服电机、PZEX424VDC4n、风机水泵、PLC、触摸屏
- 主营：SMC、FESTO
- 主营：调压阀、安全门、t18vp6urq、i/o模块、编码器、继电器、控制器、s18sp6dlq、适配器、扫描仪、mhza2-6d3、传感器、芯片卡、指示灯、qs186leq5、据载体、皮尔磁、k50lgrxpq、k50lgrypq、pbt46u-vl、tfp104-000、mqdec2-530、qs18vp6rq8、miad9dw/30、2600r010on
- 主营：变送器、接触器、启动器、变频器、plc模块、起动器、传感器、编码器、继电器、刀开关、触摸屏、断路器、压力表、400w电机、电源模块、操作面板、电机马达、总线模块、扩展模块、开关电源、接近开关、开关插座、隔离开关、风机水泵、伺服电机