4-(Methylthio)benzyl Chloride

Updated: 2026-07-15

Overview

4-(Methylthio)benzyl Chloride is an organic compound primarily used as an intermediate in chemical synthesis. Its reactive benzyl chloride group makes it valuable for introducing the 4-(methylthio)benzyl moiety into more complex molecules. The compound is commonly employed in the pharmaceutical and agrochemical industries due to its ability to serve as a building block for active ingredients. While not widely known outside industrial applications, 4-(Methylthio)benzyl Chloride plays a crucial role in the production of various specialty chemicals. Its synthesis typically involves the chlorination of 4-(methylthio)benzyl alcohol or related precursors under controlled conditions.

Physical and Chemical Properties

4-(Methylthio)benzyl Chloride is a colorless to pale yellow liquid at room temperature with a characteristic pungent odor. The compound has a molecular weight of 172.67 g/mol and a density of approximately 1.18 g/cm³. It shows good solubility in common organic solvents but is generally insoluble in water. The molecule consists of a benzene ring substituted with a methylthio (-SCH3) group at the para position and a chloromethyl (-CH2Cl) group. This structure makes it reactive toward nucleophiles, particularly in substitution reactions where the chlorine atom can be displaced by other functional groups.

Main Applications

The primary use of 4-(Methylthio)benzyl Chloride is as a chemical intermediate in organic synthesis. In the pharmaceutical industry, it serves as a precursor for various drug molecules, particularly those containing the 4-(methylthio)benzyl moiety. The compound's reactivity allows for the construction of more complex molecular architectures. In agrochemical applications, 4-(Methylthio)benzyl Chloride is used to synthesize certain pesticides and herbicides. Its ability to introduce sulfur-containing groups makes it valuable for creating compounds with specific biological activities. Additionally, it finds use in specialty chemical production, particularly in the synthesis of dyes and other functional materials.

Safety and Storage

4-(Methylthio)benzyl Chloride requires careful handling due to its corrosive nature and potential health hazards. Direct contact can cause skin and eye irritation, while inhalation of vapors may lead to respiratory discomfort. Appropriate personal protective equipment (PPE), including gloves, goggles, and respiratory protection, should be used when handling this chemical. Storage conditions should maintain the compound in a cool, dry environment away from moisture and incompatible substances. Containers should be tightly sealed and made of materials resistant to corrosion. In case of spills, absorb with inert material and dispose of according to local regulations. Always consult the material safety data sheet (MSDS) for specific handling instructions.

B2B Procurement Guide

When procuring 4-(Methylthio)benzyl Chloride for industrial use, buyers should verify the supplier's credentials and quality control measures. Key specifications to confirm include purity level (typically 97-99%), CAS number (7205-90-5), and appropriate packaging. Technical grade is usually sufficient for most industrial applications. Lead times may vary depending on production schedules and order quantities. It's advisable to establish long-term relationships with reliable suppliers to ensure consistent quality and availability. For international shipments, ensure compliance with all transportation regulations for hazardous chemicals. Consider requesting samples for quality verification before large purchases.