Overview
4-Methylacetophenone, also known as p-Methylacetophenone, is an organic compound belonging to the acetophenone family. It is characterized by its aromatic odor and is commonly used in the fragrance and pharmaceutical industries. The compound is synthesized through the Friedel-Crafts acylation of toluene with acetic anhydride or acetyl chloride. In industrial settings, 4-Methylacetophenone is valued for its role as an intermediate in organic synthesis. Its chemical stability and reactivity make it a versatile building block for more complex molecules. The compound is typically supplied as a colorless to pale yellow liquid, with purity levels varying based on application requirements.
Physical and Chemical Properties
4-Methylacetophenone exhibits a density of approximately 1.005 g/cm³ at 20°C and a boiling point of 226°C. It is soluble in most organic solvents, such as ethanol and ether, but has limited solubility in water. The compound's aromatic structure contributes to its distinct odor, which is often described as sweet or floral. Chemically, 4-Methylacetophenone is reactive with strong oxidizing agents and should be handled with care to avoid combustion. Its melting point is -23°C, making it a liquid at room temperature. The molecular weight is 134.18 g/mol, and its CAS number is 122-00-9, which is essential for identification in regulatory and procurement contexts.
Main Applications
The primary use of 4-Methylacetophenone is in the fragrance industry, where it serves as a key ingredient in perfumes and scented products. Its aromatic profile adds floral and fruity notes, making it popular in cosmetic and personal care formulations. In pharmaceuticals, 4-Methylacetophenone acts as an intermediate in the synthesis of active pharmaceutical ingredients (APIs). It is also utilized in organic chemistry research for constructing complex molecular structures. Additionally, the compound finds niche applications in agrochemicals and specialty chemicals, where its reactivity is leveraged for targeted syntheses.
Safety and Storage
4-Methylacetophenone is flammable and should be stored away from heat, sparks, and open flames. Proper storage conditions include a cool, dry, and well-ventilated area, preferably in a tightly sealed container to prevent evaporation and contamination. Safety precautions include the use of personal protective equipment (PPE) such as gloves, goggles, and lab coats. Inhalation or skin contact should be avoided, as the compound may cause irritation. In case of exposure, rinse thoroughly with water and seek medical attention if necessary. Always refer to the material safety data sheet (MSDS) for detailed handling instructions.
B2B Procurement Guide
When procuring 4-Methylacetophenone, buyers should prioritize suppliers with verified certifications and a track record of quality compliance. Key factors to consider include purity levels (typically 98% or higher), packaging options (e.g., drums or totes), and bulk pricing discounts. It is advisable to request samples for quality testing before placing large orders. Ensure that the supplier provides proper documentation, including CAS number verification and safety data sheets. Lead times and logistics should also be evaluated to align with production schedules. For reference, the price ranges between $20 and $50 per kg, depending on quantity and purity.
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