Overview
4-Methoxypyridine is an organic compound belonging to the pyridine family, characterized by a methoxy group attached to the fourth carbon of the pyridine ring. It is widely used in pharmaceutical synthesis and as a reagent in organic chemistry due to its weakly basic properties and stability. This compound is typically available as a colorless to pale yellow liquid and is soluble in both water and common organic solvents. Its versatility makes it a valuable intermediate in the production of various drugs and specialty chemicals.
Physical and Chemical Properties
4-Methoxypyridine has a molecular weight of 109.13 g/mol and a boiling point of 172-174 °C. Its density is approximately 1.03 g/cm³, and it exhibits weak basicity, making it useful in reactions requiring mild bases. The compound is stable under normal conditions but should be handled with care to avoid exposure to heat or open flames. Its solubility in both polar and non-polar solvents enhances its utility in diverse chemical processes.
Main Applications
4-Methoxypyridine serves as a key intermediate in the synthesis of pharmaceuticals, including antihistamines and antiviral drugs. Its weakly basic nature makes it suitable for use as a catalyst or reagent in organic synthesis. Additionally, it is employed in the production of agrochemicals and specialty chemicals. Its ability to act as a ligand in coordination chemistry further expands its applications in industrial and research settings.
Safety and Storage
Proper handling of 4-Methoxypyridine is essential to ensure safety. It should be stored in a cool, dry, well-ventilated area away from heat sources and open flames. Personal protective equipment, including gloves and goggles, is recommended during use. In case of exposure, immediate measures such as rinsing with water and seeking medical attention are advised. The compound should be kept away from incompatible materials, including strong oxidizing agents.
B2B Procurement Guide
When procuring 4-Methoxypyridine, buyers should prioritize suppliers with a proven track record of quality and reliability. Key considerations include verifying the compound's purity, typically specified as ≥98%, and ensuring compliance with relevant regulatory standards. Bulk purchases may offer cost advantages, but storage conditions must be carefully managed to maintain product integrity. It is also advisable to request safety data sheets (SDS) and certificates of analysis (CoA) from suppliers.
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