4''-Methoxydaidzin

Updated: 2026-08-05

Overview

4'-Methoxydaidzein is a methoxylated derivative of daidzein, a naturally occurring isoflavone found in soybeans and other legumes. It is synthesized for research and industrial applications due to its modified biological activity compared to its parent compound. The methoxy group at the 4' position enhances its stability and alters its interaction with cellular receptors, making it valuable in pharmacological studies. This compound is primarily used in academic and industrial research focused on hormone-related conditions, oxidative stress, and inflammation. Its structural similarity to estrogen allows it to bind selectively to estrogen receptors, though with distinct effects that are under investigation for therapeutic potential.

Physical and Chemical Properties

4'-Methoxydaidzein is characterized by its crystalline solid form and limited solubility in aqueous solutions, which necessitates organic solvents like dimethyl sulfoxide (DMSO) for laboratory use. Its molecular weight of 284.26 g/mol and melting point range of 220-225°C reflect its moderate stability under standard conditions. Spectroscopic methods such as NMR and HPLC are typically employed to confirm its purity and structural integrity. The compound exhibits UV absorption maxima around 260-280 nm, a property utilized in analytical quantification. Its stability is compromised by prolonged exposure to light or high temperatures, requiring controlled storage environments.

Main Applications

In pharmaceuticals, 4'-Methoxydaidzein is investigated for its potential to modulate estrogen receptor activity, particularly in breast cancer and menopausal symptom research. Its antioxidant properties also make it a candidate for nutraceutical formulations aimed at reducing oxidative stress-related damage. Industrially, it serves as a reference standard in quality control for soy-derived products and as an intermediate in synthesizing more complex bioactive molecules. Research institutions procure it for in vitro and in vivo studies exploring its pharmacokinetics and mechanisms of action.

Safety and Storage

While 4'-Methoxydaidzein is not classified as highly hazardous, standard laboratory precautions are advised. Use gloves, goggles, and respirators when handling powders to prevent inhalation or skin contact. Spills should be contained with inert absorbents and disposed of following local regulations. Long-term storage requires refrigeration (2-8°C) in airtight, light-resistant containers to prevent degradation. Suppliers often provide stability data under these conditions, with typical shelf lives of 2-3 years when stored properly.

B2B Procurement Guide

Bulk buyers should prioritize suppliers with ISO certification and detailed analytical reports (e.g., HPLC, MS) to ensure compound purity and identity. Pricing varies significantly based on order volume (grams to kilograms) and purity grades (≥95% to ≥98%). Request samples for in-house validation before large purchases, especially for research applications where batch-to-batch consistency is critical. Contract manufacturing options may be available for customized derivatives or formulations.