4-Methoxy-2-nitroacetophenone

Updated: 2026-09-12

Overview

4-Methoxy-2-nitroacetophenone is an organic compound with the molecular formula C9H9NO4. It is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. The compound is characterized by its yellow to light brown crystalline appearance and solubility in common organic solvents. Due to its nitro and methoxy functional groups, 4-Methoxy-2-nitroacetophenone is a versatile building block in organic chemistry. Its applications span across various industries, including pharmaceuticals, agrochemicals, and specialty chemicals.

Physical and Chemical Properties

4-Methoxy-2-nitroacetophenone is a yellow to light brown crystalline powder with a molecular weight of 195.17 g/mol. It is soluble in organic solvents such as ethanol and acetone but has limited solubility in water. The compound's exact melting and boiling points are not widely documented, but it is stable under typical storage conditions. The presence of both nitro and methoxy groups on the aromatic ring contributes to its reactivity, making it useful in various chemical reactions. Its stability and solubility profile make it suitable for use in laboratory and industrial settings.

Main Applications

4-Methoxy-2-nitroacetophenone is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Its reactive nitro group allows for further functionalization, making it valuable in the production of active pharmaceutical ingredients (APIs). In addition to pharmaceuticals, this compound is employed in the synthesis of dyes, fragrances, and other specialty chemicals. Its versatility and ease of handling make it a preferred choice for researchers and manufacturers in the chemical industry.

Safety and Storage

4-Methoxy-2-nitroacetophenone should be handled with care to avoid inhalation, ingestion, or skin contact. Proper personal protective equipment (PPE), such as gloves and goggles, should be worn when handling this compound. It should be stored in a cool, dry place away from direct sunlight and moisture to maintain its stability. In case of accidental exposure, immediate medical attention is recommended. Proper disposal methods should be followed to minimize environmental impact. Always refer to the material safety data sheet (MSDS) for detailed safety information.

B2B Procurement Guide

When procuring 4-Methoxy-2-nitroacetophenone, it is essential to verify the supplier's reliability and the product's purity. Requesting a Certificate of Analysis (COA) can help ensure the compound meets the required specifications. Bulk purchases may offer cost advantages, but storage conditions should be considered to maintain product integrity. Prices can vary depending on the supplier and quantity ordered. It is advisable to compare quotes from multiple vendors and consider lead times and shipping conditions. Establishing long-term partnerships with reputable suppliers can ensure consistent quality and supply.