Overview
4-Hydroxypropiophenone is an aromatic organic compound belonging to the class of hydroxy ketones. It features both a hydroxyl group (-OH) and a propiophenone group, making it versatile in chemical synthesis. The compound is primarily synthesized through Friedel-Crafts acylation or other organic reactions. Industrially, it serves as a key intermediate in pharmaceuticals, particularly for drugs targeting cardiovascular and neurological conditions. Its stability and reactivity also make it valuable in fragrance manufacturing and polymer stabilization.
Physical and Chemical Properties
4-Hydroxypropiophenone appears as a white to off-white crystalline powder with a characteristic mild odor. It has a melting point range of 148–152°C, indicating moderate thermal stability. The compound is soluble in organic solvents like ethanol and methanol but has limited solubility in water. Its chemical structure includes a benzene ring substituted with a hydroxyl group and a propiophenone moiety. This configuration allows for electrophilic substitution reactions, making it useful in further derivatization. The compound is stable under standard conditions but may degrade under strong acids, bases, or UV exposure.
Main Applications
In the pharmaceutical industry, 4-hydroxypropiophenone is a precursor for synthesizing active pharmaceutical ingredients (APIs), including beta-blockers and antidepressants. Its hydroxyl group facilitates further functionalization, enabling tailored drug designs. The fragrance industry employs it as a building block for musk and floral scent compounds. Additionally, it acts as a UV stabilizer in plastics and coatings, where it scavenges free radicals to prevent polymer degradation. Smaller quantities are used in research laboratories for organic synthesis studies.
Safety and Storage
While 4-hydroxypropiophenone is not highly toxic, it can cause irritation upon contact with skin, eyes, or respiratory tracts. Proper personal protective equipment (PPE), such as gloves and goggles, is recommended during handling. Avoid generating dust or fumes. Storage requires a cool, dry environment in tightly sealed containers to prevent moisture absorption and oxidation. Incompatible materials include strong oxidizers and corrosive agents. Spills should be contained with inert absorbents and disposed of following local regulations.
B2B Procurement Guide
When sourcing 4-hydroxypropiophenone, prioritize suppliers with certified manufacturing practices (e.g., GMP, ISO). Confirm the product’s purity (typically ≥98%) via COA (Certificate of Analysis) and validate the CAS number (70-70-2) to avoid counterfeit materials. Bulk buyers should negotiate prices based on volume, with reference rates ranging from $50–$100/kg. Consider logistics: the compound is non-hazardous for transport but may require climate-controlled shipping for long distances. Sample testing is advised for quality assurance before large-scale procurement.
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