4-Hydroxyethylpyridine

Updated: 2026-09-15

Overview

4-Hydroxyethylpyridine is an organic compound belonging to the pyridine family. It is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. Its reactive hydroxyl and pyridine groups make it a versatile building block in organic chemistry. The compound is typically supplied as a colorless to pale yellow liquid with a characteristic odor. It is commercially available in various purity grades, with higher purity grades preferred for pharmaceutical applications. Industrial-scale production involves catalytic processes, ensuring cost-effectiveness for bulk procurement.

Physical and Chemical Properties

4-Hydroxyethylpyridine exhibits a density of 1.08 g/cm³ and a boiling point range of 220-222°C. It is soluble in water and most organic solvents, including ethanol, acetone, and dichloromethane. The compound's hydroxyl group contributes to its polarity, enabling reactions such as esterification and etherification. Its pyridine ring provides basicity, allowing it to participate in acid-base reactions and coordinate with metal ions. The compound is stable under normal storage conditions but should be protected from strong oxidizers to prevent decomposition or hazardous reactions.

Main Applications

In the pharmaceutical industry, 4-Hydroxyethylpyridine serves as a precursor for drugs targeting neurological and cardiovascular conditions. Its derivatives are explored for their bioactivity and potential therapeutic effects. The agrochemical sector uses it to synthesize pesticides and herbicides with enhanced efficacy. Additionally, the compound is employed in chemical research as a ligand or catalyst in organic synthesis. Its dual functional groups make it valuable for creating complex molecules, including polymers and specialty coatings. Industrial applications also include its use in corrosion inhibitors and surfactants.

Safety and Storage

4-Hydroxyethylpyridine is classified as an irritant, requiring careful handling to avoid skin or eye contact. Personal protective equipment (PPE) such as gloves, goggles, and lab coats is recommended. In case of exposure, rinse affected areas with plenty of water and seek medical advice if irritation persists. Storage should be in tightly sealed containers, away from heat sources and direct sunlight. The compound is flammable, so fire safety measures must be in place. Proper ventilation is essential to prevent vapor accumulation, which could pose inhalation risks.

B2B Procurement Guide

When sourcing 4-Hydroxyethylpyridine, prioritize suppliers with ISO or GMP certifications to ensure product quality. Request certificates of analysis (CoA) to verify purity, typically ranging from 98% to 99.5%. Bulk purchases (e.g., drum quantities) often attract discounts, but confirm storage compatibility with your facilities. Logistics planning should account for the compound's flammability, requiring compliant transportation. Establish long-term contracts with reliable suppliers to secure stable pricing and availability. For niche applications, custom synthesis options may be available from specialized manufacturers.