Overview
4'-Hydroxy-3'-nitroacetophenone is an organic compound featuring both hydroxyl and nitro functional groups attached to an acetophenone backbone. It is primarily used as an intermediate in pharmaceutical and agrochemical synthesis due to its reactivity and structural properties. The compound is typically supplied as a yellow to light brown crystalline powder. Its synthesis involves nitration of 4-hydroxyacetophenone, yielding a product with applications in fine chemicals and specialty materials. The presence of both electron-donating (hydroxyl) and electron-withdrawing (nitro) groups makes it valuable for further chemical transformations.
Physical and Chemical Properties
The compound exhibits moderate solubility in polar organic solvents like ethanol and acetone but is only sparingly soluble in water. Its melting point ranges between 150-155°C, which is typical for aromatic nitro compounds. The molecular weight is 181.15 g/mol, with a molecular formula of C8H7NO4. Key chemical properties include reactivity at the nitro and hydroxyl sites, enabling its use in condensation and substitution reactions. The nitro group can be reduced to an amine, while the hydroxyl group can participate in etherification or esterification processes, making it versatile for synthetic applications.
Main Applications
4'-Hydroxy-3'-nitroacetophenone serves as a key intermediate in pharmaceutical manufacturing, particularly for drugs targeting cardiovascular and central nervous system disorders. Its nitro group is often reduced to form amino derivatives, which are building blocks for active pharmaceutical ingredients (APIs). In agrochemicals, it is used to synthesize herbicides and fungicides. The compound also finds niche applications in dye production, where its aromatic structure contributes to chromophore development. Its dual functionality allows for diverse downstream chemical modifications.
Safety and Storage
Due to its nitro and hydroxyl groups, the compound requires careful handling to avoid skin irritation or respiratory issues. Personal protective equipment (PPE) such as gloves, goggles, and lab coats is recommended. It should be stored in a tightly sealed container in a cool, dry environment away from direct sunlight and incompatible substances like strong oxidizers. In case of exposure, rinse affected areas with water and seek medical advice if symptoms persist. Spills should be contained with absorbent materials and disposed of according to local regulations for nitroaromatic compounds.
B2B Procurement Guide
When procuring 4'-Hydroxy-3'-nitroacetophenone, prioritize suppliers with certifications like ISO or GMP to ensure quality consistency. Request detailed technical data sheets (TDS) and certificates of analysis (CoA) to verify purity, typically ≥98% for industrial use. Bulk buyers should negotiate pricing based on volume, with prices varying by supplier and region. Consider logistics factors such as shipping conditions (e.g., temperature-controlled transport for sensitive batches) and lead times. Establish long-term contracts with reliable suppliers to mitigate supply chain disruptions, especially for pharmaceutical-grade material.
Related Manufacturers
- 主营：二甲基亚砜、乙二醇、丙二醇、羟基、DMAC
- 主营：甜菊糖、氯乙酰、二乙苯、4316-73-8、4861-19-2、7783-40-6、8002-74-2、2842-44-6、1310-58-3、酞菁绿、阻燃剂、二戊烯、单甲醚、硫酸锂、大理石、1192-62-7、羊脂酸、磷酸氢、7782-61-8、龙脑油、聚甘油、二聚酸、戊二醇、聚醚f68、磺化油
- 主营：硼酸酐、阻聚剂、己二酸、羟基、氯化锂、发泡剂、乙二醇、醋酸铜、硅酸钠、正癸醇、新癸酸、环烷油、腰果酚、十二醇、酒石酸、碳酸锂、三甘醇、油菜酸、二甘醇、碳酸钾、甲酸钠、硅酸镁、棕榈油、6-氯嘌呤、微晶石蜡、磷酸一铵
- 主营：阻燃剂、乙酸镍、乙酸镝、羟基、硫酸锂、硫酸锶、溴氨酸、香茅醇、肌氨酸、锂电池、四氢萘、磷酸铬、碳酸镁、碳酸镍、防冻剂、磷酸铝、叔丁醇、氟苯基、浮选剂、稀释剂、羟乙基、去除剂、庚二酸、除磷剂、十八烯、蛋白酶
- 主营：苯肼、氯甲基苯乙烯、无水氯化锂、邻硝基苯磺酰氯、4-二氢吡喃、4-溴靛红、四羟基二硼、丙酰乙酸甲酯、碘甲烷、亚磷酸三苯酯、苯并噻唑、苄胺、苯基锂、叔丁醇钾、三丁基膦
- 主营：乙二醇、二甲基亚砜、丙二醇、4-丁二醇、精对苯二甲酸、己二酸、聚乙烯醇、聚乙二醇、木质素、甘油、三甘醇、己内酰胺、叔十二硫醇、白油、对苯二甲酸二甲酯
- 主营：山梨酸钾、吡唑啉酮、清凉茶酸、羟基嘧啶、山梨酸钙、磺酸苯基、叔丁基锂、双乙烯酮、基氨基锂、氯乙酰氯、三正丁基、四羟甲基、乙酰苯胺、甲基苯基、氯羟吡啶、硫酸磷脲
- 主营：氯菊酯、转移剂、聚酯树脂、对羟基苯甲醚、二甲氧基、驱蚊原液、食品香料、缩水甘油酯、蚊香增效剂、丙烯酸缩水、环氧稀释剂、硅烷偶联剂、超疏水材料、对甲氧基苯酚、乙烯基双封头、苯基缩水甘油醚
- 主营：硫酸铝、硫酸铁、除草剂、羟基、芥花籽油、全氟萘烷、桂花精油、乳清酸锂、分析试剂、无色液体、香精香料、农药中间体、淡黄色液体、巯基乙酸钙、化工催化剂、乙酰基六肽、医药中间体、表面活性剂、香料化合物、草酸二水合物、三硫代碳酸钠、二硫氰基甲烷、甲基天冬氨酸、精胺四盐酸盐、苯乙烯化苯酚、硫脲类促进剂
- 主营：碘化钾、剂原料、王浆酸、还原红41、肉桂酸、特戊醛、氰酸钠、己二酸、黄原胶、麝香105、辛酸乙酯、油胺原料、柠檬酸钠、癸醛原料、化工原料、丙酸苄酯、甲基磺酸、异丙碘胺、双盐酸肼、碘类原料、有机化工、胍基乙酸、环保原料、防腐原料、苦精原料
- 主营：苯乙酮、硫磺粉末
- 主营：冲压油、苯酚cas、乙烯基、cas71-41-0、4二碘苯、cas106-47-8、cas123-30-8、cas563-47-3、141b清洗剂、底涂剂、cas95-50-1、cas120-82-1、cas110-87-2、cas110-00-9、cas100-50-5、cas110-82-7、异构烷烃、甲基乙撑、白色粉末、丙撑二胺、板助焊剂、脱漆剂
- 主营：苯乙酮、萃取剂、选矿药剂、金矿硫化矿
- 主营：苯酚、二甲基亚砜、己二酸、羟基、乙二醇、冰乙酸、环己酮、氯化亚砜、四氢呋喃、三乙醇胺、甲基叔丁基醚、醋酸乙酯、二甲苯、异戊醇、环己烷、苯乙烯、正丁醇
- 主营：硝基、咪唑、原甲酸三乙酯、N-二甲基乙醇胺