Overview
4'-Hydroxy-3'-methylacetophenone is an organic compound belonging to the acetophenone family. It is characterized by a hydroxyl group at the 4' position and a methyl group at the 3' position on the benzene ring. This compound is widely used as an intermediate in pharmaceutical synthesis and fragrance production. Its aromatic structure and functional groups make it a versatile building block in organic chemistry. The compound is typically synthesized through Friedel-Crafts acylation or other aromatic substitution reactions. Its purity and stability are critical for industrial applications.
Physical and Chemical Properties
4'-Hydroxy-3'-methylacetophenone is a white to off-white crystalline powder with a molecular weight of 150.17 g/mol. It has a melting point of approximately 125-128°C and is soluble in common organic solvents like ethanol and acetone. The compound exhibits typical aromatic ketone reactivity, including participation in condensation and oxidation reactions. Its hydroxyl group enhances solubility in polar solvents and allows for further functionalization. The presence of both electron-donating (hydroxyl) and electron-withdrawing (carbonyl) groups creates unique electronic properties.
Main Applications
In the pharmaceutical industry, 4'-Hydroxy-3'-methylacetophenone serves as a key intermediate for synthesizing various drugs, including anti-inflammatory and analgesic compounds. Its structural features make it valuable for creating complex molecular architectures. The fragrance industry utilizes this compound as a precursor for musk-like scents and other aromatic chemicals. Additionally, it finds use in UV absorber formulations for plastics and coatings, where its conjugated system helps absorb harmful ultraviolet radiation.
Safety and Storage
Proper handling of 4'-Hydroxy-3'-methylacetophenone requires personal protective equipment, including gloves and safety goggles. The compound may cause irritation upon contact with skin or eyes, and inhalation of dust should be avoided. Storage recommendations include keeping the material in a tightly sealed container in a cool, dry place away from direct sunlight. Compatibility with other chemicals should be verified before mixing, and appropriate ventilation is necessary in working areas.
B2B Procurement Guide
When procuring 4'-Hydroxy-3'-methylacetophenone, buyers should prioritize suppliers who provide comprehensive product specifications, including purity levels (typically 98% or higher) and batch analysis certificates. Minimum order quantities often range from 1 to 25 kilograms. Quality verification through third-party testing may be advisable for large orders. Lead times vary depending on supplier inventory, with typical delivery periods of 2-4 weeks for custom orders. Bulk purchasing may offer cost advantages, but proper storage capacity should be ensured.
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