Overview
4'-Hydroxy-2'-methylacetophenone is an organic compound belonging to the class of aromatic ketones. It is widely used as an intermediate in the synthesis of pharmaceuticals, fragrances, and UV absorbers. The compound features a hydroxyl group and a methyl group attached to an acetophenone backbone, making it versatile for various chemical reactions. Its significance in industrial applications stems from its ability to undergo further functionalization, enabling the production of more complex molecules. The compound is typically synthesized through Friedel-Crafts acylation or other organic reactions, ensuring high purity for specialized uses.
Physical and Chemical Properties
4'-Hydroxy-2'-methylacetophenone appears as a white to pale yellow crystalline powder with a characteristic aromatic odor. It has a melting point range of 128-132°C, indicating moderate thermal stability. The compound is soluble in common organic solvents such as ethanol, ether, and acetone but exhibits limited solubility in water. The presence of both hydroxyl and carbonyl functional groups allows it to participate in hydrogen bonding and electrophilic reactions. Its molecular weight of 150.17 g/mol and aromatic structure contribute to its stability under standard conditions, making it suitable for storage and handling in industrial settings.
Main Applications
This compound serves as a key intermediate in the pharmaceutical industry, where it is used to synthesize active pharmaceutical ingredients (APIs) and other therapeutic agents. Its aromatic properties also make it valuable in the fragrance industry, contributing to the production of perfumes and flavoring agents. Additionally, 4'-Hydroxy-2'-methylacetophenone is employed in the manufacture of UV absorbers, which are critical components in sunscreens and coatings. Its versatility in organic synthesis further extends to agrochemicals and specialty chemicals, highlighting its broad utility across multiple sectors.
Safety and Storage
Handling 4'-Hydroxy-2'-methylacetophenone requires adherence to standard safety protocols to minimize exposure risks. The compound may cause irritation upon contact with skin or eyes, and inhalation of dust should be avoided. Proper personal protective equipment (PPE), including gloves and goggles, is recommended during use. Storage conditions should prioritize a cool, dry environment away from direct light and moisture to prevent degradation. Containers must be tightly sealed to maintain purity and prevent contamination. In case of spills, absorbent materials should be used, and the area ventilated to ensure safe cleanup.
B2B Procurement Guide
When procuring 4'-Hydroxy-2'-methylacetophenone, buyers should verify the CAS number (876-02-8) to ensure product authenticity. Purity levels, typically ranging from 98% to 99%, should be confirmed through supplier documentation or third-party testing. Reliable suppliers often provide technical data sheets (TDS) and material safety data sheets (MSDS) for compliance and safety reference. Bulk purchases may offer cost advantages, but buyers should assess storage capabilities to maintain product integrity. Establishing long-term partnerships with certified suppliers can ensure consistent quality and availability.
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