4-Hexylresorcinol

Updated: 2026-07-15

Overview

4-Hexylresorcinol is an organic compound derived from resorcinol, featuring a hexyl group attached to the benzene ring. It is widely recognized for its antiseptic and anesthetic properties, making it valuable in medical and cosmetic applications. The compound is synthesized through alkylation of resorcinol and is often used in formulations requiring antimicrobial or preservative effects. Due to its dual functionality as both an antiseptic and a local anesthetic, 4-hexylresorcinol is commonly incorporated into throat lozenges, skin care products, and topical treatments. Its antioxidant properties also make it useful in food preservation, where it helps prevent spoilage and oxidation.

Physical and Chemical Properties

4-Hexylresorcinol appears as a white to pale yellow crystalline powder with a faint phenolic odor. It has a melting point range of 62-67°C and is soluble in organic solvents like ethanol and ether, though only slightly soluble in water. The compound is stable under normal storage conditions but may degrade when exposed to prolonged light or moisture. Its molecular structure includes a phenolic hydroxyl group, which contributes to its antioxidant activity. The hexyl side chain enhances its lipid solubility, allowing it to penetrate biological membranes effectively. These properties are critical for its efficacy in antiseptic and anesthetic applications.

Main Applications

In the pharmaceutical industry, 4-hexylresorcinol is used in throat lozenges and cough syrups for its local anesthetic and antiseptic effects. It is also found in topical antiseptics and dermatological treatments for minor skin infections. The compound's ability to inhibit microbial growth makes it a preferred ingredient in personal care products like soaps and mouthwashes. Beyond healthcare, 4-hexylresorcinol serves as a food preservative, particularly in seafood, to prevent melanosis (black spot formation). Its antioxidant properties help extend shelf life by slowing oxidation. Additionally, it is used in industrial applications, such as a stabilizer in polymer production.

Safety and Storage

While 4-hexylresorcinol is generally safe for use in regulated concentrations, it can cause skin and eye irritation upon direct contact. Proper handling with gloves and goggles is recommended. Ingestion or inhalation of large quantities may lead to gastrointestinal or respiratory distress, requiring immediate medical attention. Storage should be in a cool, dry environment, away from direct sunlight and moisture to maintain stability. Containers must be tightly sealed to prevent contamination or degradation. For bulk procurement, ensure compliance with regional safety regulations and material safety data sheet (MSDS) guidelines.

B2B Procurement Guide

When sourcing 4-hexylresorcinol, verify the supplier's adherence to pharmaceutical or food-grade standards, depending on the intended use. Request certificates of analysis (CoA) to confirm purity, typically ≥98%. Pricing varies based on quantity and purity, with bulk purchases (e.g., 100 kg or more) often qualifying for discounts. Consider logistics, as the compound may require temperature-controlled transport to prevent melting or degradation. Establish long-term contracts with reliable suppliers to ensure consistent quality and avoid supply chain disruptions. For niche applications, custom formulations or derivatives may be available upon request.