Overview
4-Fluorophenyl acetate is an organic compound widely used as an intermediate in pharmaceutical and chemical industries. It is derived from the esterification of 4-fluorophenol with acetic acid, resulting in a versatile building block for further chemical modifications. This compound is particularly valued in the synthesis of active pharmaceutical ingredients (APIs) and specialty chemicals. Its fluorine substituent enhances its reactivity, making it a preferred choice for targeted organic reactions.
Physical and Chemical Properties
4-Fluorophenyl acetate is a colorless to pale yellow liquid with a characteristic ester-like odor. It has a molecular weight of 154.14 g/mol and a density of approximately 1.18 g/cm³. The compound is soluble in common organic solvents such as ethanol, ether, and acetone but has limited solubility in water. Chemically, it is stable under normal conditions but can hydrolyze in the presence of strong acids or bases. The fluorine atom at the para position influences its electronic properties, making it useful in electrophilic aromatic substitution reactions.
Main Applications
The primary use of 4-fluorophenyl acetate is as an intermediate in the pharmaceutical industry, where it serves as a precursor for APIs and other biologically active compounds. It is also employed in the synthesis of fragrances and specialty chemicals. In research settings, this compound is utilized to study fluorine's effects on molecular reactivity and stability. Its applications extend to agrochemicals and materials science, where fluorinated compounds are increasingly in demand.
Safety and Storage
4-Fluorophenyl acetate is flammable and should be stored away from heat sources and open flames. Proper ventilation is essential to prevent vapor accumulation. Personal protective equipment (PPE), including gloves and goggles, must be worn during handling. The compound should be stored in a tightly sealed container in a cool, dry place. Incompatible materials include strong oxidizing agents and bases, which can lead to hazardous reactions. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety guidelines.
B2B Procurement Guide
When procuring 4-fluorophenyl acetate, verify the supplier's reputation and request certificates of analysis (COA) to ensure product purity and consistency. Bulk purchases may qualify for discounts, but confirm storage and handling requirements beforehand. Compare prices from multiple suppliers, but prioritize quality and reliability. Ensure the supplier complies with international safety and environmental regulations. Lead times and shipping conditions should also be considered to avoid delays or product degradation.
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