4-Fluorobenzophenone[2]

Updated: 2026-10-02

Overview

4-Fluorobenzophenone is an organic compound classified as a fluorinated benzophenone derivative. It is widely utilized as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. The compound's fluorine substitution enhances its reactivity, making it valuable for targeted chemical transformations. In industrial settings, 4-Fluorobenzophenone is prized for its stability and compatibility with various reaction conditions. Its role as a building block in organic synthesis has led to its adoption in research and commercial production across multiple sectors.

Physical and Chemical Properties

4-Fluorobenzophenone exhibits a crystalline structure with a melting point range of 66-70°C, making it solid at room temperature. Its molecular weight of 200.21 g/mol and density of approximately 1.2 g/cm³ contribute to its handling characteristics. The compound is soluble in common organic solvents such as ethanol and acetone but demonstrates negligible solubility in water. This property facilitates its use in non-aqueous reaction systems. Its stability under normal conditions is offset by reactivity with strong oxidizing agents, requiring careful storage and handling.

Main Applications

In the pharmaceutical industry, 4-Fluorobenzophenone serves as a precursor for active pharmaceutical ingredients (APIs) and drug intermediates. Its fluorine atom introduces specific electronic effects that can enhance drug potency or metabolic stability. The agrochemical sector employs this compound in synthesizing herbicides, fungicides, and other crop protection agents. Additionally, 4-Fluorobenzophenone finds use in material science applications, including UV stabilizers for polymers and specialty coatings requiring fluorinated components.

Safety and Storage

While 4-Fluorobenzophenone is not classified as highly hazardous, it may cause skin and eye irritation upon direct contact. Proper personal protective equipment (PPE), including gloves and goggles, is recommended during handling. Storage should be in tightly sealed containers, protected from light and moisture to prevent degradation. The compound is stable under recommended conditions but should be kept away from strong oxidizers to avoid unwanted reactions. Disposal must comply with local regulations for organic chemical waste.

B2B Procurement Guide

When procuring 4-Fluorobenzophenone, prioritize suppliers who provide comprehensive analytical certificates (CoA) detailing purity (typically 98-99.5%) and impurity profiles. Batch-to-batch consistency is crucial for industrial applications. Consider ordering larger quantities for bulk discounts, but verify storage capabilities to maintain product integrity. Technical support from suppliers regarding application-specific purity requirements can be valuable for specialized uses. Lead times may vary based on production schedules, so early planning is advised for critical projects.