4-Fluoro-3-methoxyacetophenone

Updated: 2026-07-15

Overview

4-Fluoro-3-methoxyacetophenone is an aromatic ketone used primarily as an intermediate in pharmaceutical and fine chemical synthesis. Its molecular structure includes a fluorine atom and a methoxy group, which influence its reactivity and applications. The compound is valued for its role in producing active pharmaceutical ingredients (APIs) and other specialized chemicals. This compound is typically supplied as a white to off-white crystalline powder. It is stable under normal conditions but should be handled with care due to potential health hazards. Its synthesis involves multi-step organic reactions, often starting from fluorinated benzene derivatives.

Physical and Chemical Properties

4-Fluoro-3-methoxyacetophenone has a molecular weight of 168.16 g/mol and a melting point range of 60-65°C. It is soluble in common organic solvents like ethanol, acetone, and dimethyl sulfoxide (DMSO), but has limited solubility in water. The presence of the fluorine atom enhances its electronegativity, making it useful in specific chemical reactions. The compound is relatively stable under standard storage conditions but may degrade when exposed to strong oxidizing agents or prolonged heat. Its infrared (IR) and nuclear magnetic resonance (NMR) spectra are commonly used for identification and purity verification in laboratory settings.

Main Applications

The primary use of 4-Fluoro-3-methoxyacetophenone is in the pharmaceutical industry, where it serves as a building block for APIs. It is particularly valuable in synthesizing compounds with biological activity, such as anti-inflammatory or antimicrobial agents. In addition to pharmaceuticals, this compound finds applications in agrochemicals and specialty chemicals. Its fluorine moiety often enhances the bioactivity and stability of the final products. Research laboratories also use it as a reagent in organic synthesis and material science studies.

Safety and Storage

4-Fluoro-3-methoxyacetophenone should be handled with caution to avoid health risks. Inhalation, ingestion, or skin contact can cause irritation or more severe effects. Always use PPE, including gloves, goggles, and lab coats, when working with this chemical. Store the compound in a tightly sealed container in a cool, dry place away from light and moisture. Keep it separate from strong oxidizing agents to prevent hazardous reactions. Proper disposal methods should follow local regulations for chemical waste.

B2B Procurement Guide

When procuring 4-Fluoro-3-methoxyacetophenone, verify the CAS number (456-03-1) and purity specifications, which typically range from 95% to 99%. Suppliers may offer technical or analytical grades, depending on the intended use. Bulk orders often require lead time for custom synthesis. Request certificates of analysis (CoA) and material safety data sheets (MSDS) to ensure compliance with safety and quality standards. Prices vary based on quantity and purity, with discounts available for large-scale purchases.