Overview
4'-Ethylacetophenone is an aromatic ketone with the molecular formula C10H12O. It is a colorless to pale yellow liquid with a characteristic sweet, floral odor. The compound is primarily used as an intermediate in the synthesis of pharmaceuticals, fragrances, and other fine chemicals. Its structure consists of an acetyl group attached to a 4-ethylphenyl ring, making it a versatile building block in organic chemistry. Industrially, it is produced through Friedel-Crafts acylation or other catalytic processes.
Physical and Chemical Properties
4'-Ethylacetophenone has a molecular weight of 148.20 g/mol and a density of approximately 1.01 g/cm³. It boils at around 245-247°C and is soluble in common organic solvents like ethanol, ether, and acetone, though it has limited solubility in water. The compound exhibits typical ketone reactivity, including participation in condensation and reduction reactions. Its aromatic ring further allows for electrophilic substitution reactions, making it useful in multi-step synthetic pathways.
Main Applications
In the pharmaceutical industry, 4'-Ethylacetophenone serves as a precursor for active pharmaceutical ingredients (APIs) and drug intermediates. Its structural features are valuable in designing molecules with specific biological activities. It is also widely employed in fragrance manufacturing, contributing to floral and fruity scent profiles. Additionally, the compound finds use in agrochemicals and specialty polymers, where its reactivity enables the creation of custom chemical architectures.
Safety and Storage
As a chemical intermediate, 4'-Ethylacetophenone requires careful handling. It is classified as an irritant to skin and eyes, and prolonged exposure should be avoided. Proper personal protective equipment (PPE), including gloves and goggles, is essential during use. Storage should be in tightly sealed containers, away from heat sources and oxidizing agents. The compound is stable under recommended conditions but may decompose if exposed to extreme temperatures or incompatible materials.
B2B Procurement Guide
When procuring 4'-Ethylacetophenone, prioritize suppliers with certifications such as ISO or GMP to ensure quality and consistency. Key specifications to verify include purity (typically ≥98%), water content, and absence of heavy metals. Bulk buyers should negotiate pricing based on volume, with prices commonly ranging between $50-$150 per kilogram. Request samples for lab testing before large-scale orders, and confirm logistics options for safe transportation, especially for international shipments.
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