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4-Dihydroxycinnamic acid

Updated: 2026-08-07

Overview

4-Dihydroxycinnamic acid, commonly known as caffeic acid, is a naturally occurring phenolic compound found in various plants, including coffee, fruits, and vegetables. It is widely recognized for its antioxidant properties and is used in multiple industries, from pharmaceuticals to food additives. Caffeic acid is synthesized through the shikimate pathway in plants and has been extensively studied for its potential health benefits. Its applications range from being a key ingredient in skincare products to its use as a dietary supplement due to its anti-inflammatory effects.

Physical and Chemical Properties

4-Dihydroxycinnamic acid is a yellow crystalline powder with a molecular weight of 180.16 g/mol. It has a melting point of 223-225 °C and is soluble in water, ethanol, and acetone. The compound exhibits strong antioxidant activity due to its phenolic hydroxyl groups. Its density is approximately 1.478 g/cm³, and it is stable under normal storage conditions. However, it should be protected from prolonged exposure to light and moisture to maintain its efficacy and shelf life.

Main Applications

Caffeic acid is extensively used in the pharmaceutical industry for its anti-inflammatory and antimicrobial properties. It is a common ingredient in drugs aimed at treating oxidative stress-related conditions. In the food industry, it serves as a natural preservative and flavor enhancer. Additionally, its antioxidant properties make it a popular additive in cosmetics, particularly in anti-aging and skin-protective formulations.

Safety and Storage

While caffeic acid is generally considered safe, proper handling is essential to avoid irritation. It is recommended to use gloves and protective eyewear when handling the compound in its pure form. Storage should be in a cool, dry place, away from direct sunlight. The compound is stable under these conditions, but prolonged exposure to high temperatures or humidity can degrade its quality.

B2B Procurement Guide

When procuring 4-dihydroxycinnamic acid, it is crucial to verify the purity and supplier credentials. Reputable suppliers should provide certificates of analysis (CoA) to confirm the product's specifications. Bulk purchases often come with cost benefits, but buyers should also consider logistics and storage requirements. It is advisable to establish long-term relationships with reliable suppliers to ensure consistent quality and supply.

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