Overview
4'-Deoxydoxorubicin is a semisynthetic derivative of doxorubicin, designed to improve therapeutic outcomes while minimizing adverse effects. It belongs to the anthracycline class of antibiotics, renowned for their antitumor properties. The compound is primarily utilized in oncology for its ability to disrupt DNA replication and induce apoptosis in cancer cells. Developed as a less cardiotoxic alternative to doxorubicin, 4'-Deoxydoxorubicin retains potent cytotoxicity but with a modified sugar moiety to enhance tumor targeting. Its clinical use is supported by extensive research demonstrating efficacy against solid tumors and hematologic malignancies.
Physical and Chemical Properties
4'-Deoxydoxorubicin appears as a red-orange crystalline powder, stable under recommended storage conditions. It is soluble in polar solvents like water and DMSO, facilitating its formulation for intravenous administration. The molecular weight of 527.52 g/mol reflects its complex structure, which includes a tetracyclic aglycone and a deoxy sugar. Thermal stability is limited, with decomposition observed near its melting point. The compound's fluorescence under UV light aids in analytical detection. Its solubility profile and stability in aqueous solutions are critical for pharmaceutical preparations, requiring pH control to prevent degradation.
Main Applications
4'-Deoxydoxorubicin is clinically employed in treating aggressive cancers, particularly breast and ovarian carcinomas. Its mechanism involves intercalating into DNA strands and inhibiting topoisomerase II, leading to irreversible DNA damage and cell death. This makes it a cornerstone of combination chemotherapy regimens. Off-label uses include research applications, such as studying multidrug resistance mechanisms in cancer cell lines. The compound's specificity for rapidly dividing cells underpins its utility in oncology, though its use is carefully monitored due to potential myelosuppression and cardiac toxicity.
Safety and Storage
Due to its cytotoxic nature, 4'-Deoxydoxorubicin requires stringent handling protocols. Personnel must wear nitrile gloves, lab coats, and eye protection to avoid exposure. Spills should be neutralized with absorbent materials and disposed of as hazardous waste. Long-term storage demands temperatures below -20°C in airtight, light-resistant containers to preserve potency. Stability studies indicate degradation under oxidative conditions, necessitating inert atmospheres for bulk storage. Institutional guidelines for antineoplastic agents should be followed to mitigate occupational risks.
B2B Procurement Guide
Procuring 4'-Deoxydoxorubicin involves verifying supplier credentials, including GMP compliance and batch-specific Certificates of Analysis. Key parameters to assess are purity (≥98% by HPLC), residual solvent levels, and endotoxin testing for parenteral-grade material. Bulk buyers should negotiate cold chain logistics to ensure uninterrupted temperature control during transit. Market prices fluctuate based on synthesis complexity and demand; request quotes from multiple vendors. Consider contractual agreements for consistent supply, especially for clinical trial materials, and audit suppliers for quality assurance.
Related Manufacturers
- 主营：ckd气缸、ckd气控、asco脉冲、无杆气缸、ab伺服电机、气体遮蔽阀、紧急开放阀、吸附式干燥器、ASCO电磁阀、费斯托电磁阀、FESTO气缸、诺冠电子压力开关、贝加莱模块、博力谋、Hydac压力传感器、霍尼韦尔限位开关、伊顿叶片泵、Origa无杆气缸、邦纳传感器、Pilz继电器、松下传感器、阿托斯液压阀
- 主营：夹竹桃、异奥卡、香附酮、儿茶素、白鲜碱、管花苷、紫檀芪、木栓醇、豆甾醇、植酸锌、苏木素、泽泻醇、龙血素、黄柏酮、蚱蜢酮、防己碱、葫芦素、乌甲素、印楝素、厚朴酚、皂苷元、标准品、双黄酮、樱桃苷、芝麻素
- 主营：放大器、检测器、滤波器、调制器、发射器、接收器、衰减器、解调器、变压器、收发器、偏置器、振荡器、rfid天线、终端负载、隔直流器、微波射频、集成电路、同轴开关、接入监控ic、频率综合器、射频适配器、定向耦合器、耦合器电桥、多路复用器、rfid读取模块
- 主营：抗氧剂、乳化剂、苯扎氯铵、5124、烷基二甲基、氢化蓖麻油、表面活性剂、双链季胺盐、聚氧乙烯醚、二丁基羟基甲苯、甘油聚氧丙烯醚、十二烷基硫酸钠、树脂、助剂
- 主营：4'-联苯二酚、联苯二酚
- 主营：合成树脂、固化剂、不饱和树脂、44、环氧树脂、聚酯多元醇、酚醛树脂、医药中间体
- 主营：架桥剂、YW100 锂萃取剂、端羧基液体丁腈橡胶、10-羟基癸酸、苯乙烯磷酸、肉豆蔻酸镁、硬脂酸钴、全氟三丁胺、乙烯基磷酸二乙酯、磷酸锰铁锂、β-磷酸三钙、十一烯酸、钨酸铝、1-乙炔基环已醇、间二异丙苯、锂硅合金、溴甲酚绿、生物活性玻璃、溴代海因树脂颗粒、红铝、龙涎酮、原丁酸三甲酯
- 主营：杜仲素、对位酯、丙烯酸酯、4硝基苯D吡喃半乳糖苷、二氧化硫脲、乙基麦芽酚、饲料添加剂、油酸基硬脂酸、二苯基硅二醇
- 主营：十六烷基三甲基溴化铵、十二烷基甜菜咸、乳化剂、亚磷酸三丁酯、棕榈油、钛酸四丁酯、钛酸四乙酯
- 主营：全氟聚醚二醇、全氟三丁胺、聚硅氮烷、特种硅油、特种硅树脂
- 主营：244285、对照品、标准品
- 主营：聚苯胺、脯氨酸甲酯盐酸盐、苄基三甲基氯化铵
- 主营：无水乙醇、乙酸乙酯、磷酸、甲醇、乙二醇、二氯甲烷、异丙醇、二甲苯、各种化学试剂、化工原料
- 主营：齿轮泵、手动阀、比例阀、单向阀、电磁阀、高压泵、继电器、方向阀、螺杆泵、插装阀、五通阀、柱塞泵、过滤器、传感器、换向阀、减压阀、双联泵、母子泵、推拉缸、控制阀、调速阀、真空泵、叶片泵、液压缸、夹紧气缸
- 主营：透析袋、移液器、SIGMA、赛默飞、爱思进、康宁、离心管、巴氏吸管、保存管、封板膜、细胞爬片、滤器、ELISA试剂盒