Overview
4-Cyanophenyl, also known as p-cyanophenyl, is an aromatic nitrile compound primarily used as a versatile intermediate in organic synthesis. Its molecular structure features a benzene ring substituted with a cyano group at the para position, making it valuable for further functionalization. This compound is particularly significant in the pharmaceutical and agrochemical industries, where it serves as a building block for active ingredients. Its stability and reactivity allow for diverse chemical transformations, including nucleophilic substitutions and reductions.
Physical and Chemical Properties
4-Cyanophenyl appears as a white to off-white crystalline powder with a melting point range of 85-88°C. It is soluble in common organic solvents such as ethanol, acetone, and dimethyl sulfoxide (DMSO), but exhibits negligible solubility in water. The cyano group in 4-cyanophenyl is electron-withdrawing, influencing the compound’s reactivity in electrophilic aromatic substitution reactions. Its stability under normal conditions makes it suitable for long-term storage when protected from moisture and extreme temperatures.
Main Applications
In pharmaceuticals, 4-cyanophenyl is employed as an intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system disorders. Its nitrile group can be converted into other functional groups, such as carboxylic acids or amines. The agrochemical industry utilizes this compound in the production of herbicides and fungicides. Additionally, it finds use in specialty chemicals, including dyes and liquid crystal materials, where its aromatic structure contributes to desired electronic properties.
Safety and Storage
4-Cyanophenyl should be handled with care to avoid inhalation, ingestion, or skin contact. Personal protective equipment (PPE), including gloves and safety goggles, is recommended during handling. In case of exposure, rinse affected areas with water and seek medical attention if necessary. Storage conditions should prioritize dryness and protection from light. The compound is stable under inert atmospheres but may degrade if exposed to moisture or strong oxidizing agents. Always refer to the material safety data sheet (MSDS) for specific handling instructions.
B2B Procurement Guide
When procuring 4-cyanophenyl, buyers should confirm the CAS number (873-74-5) and specify purity requirements, typically ranging from 97% to 99%. Reputable suppliers often provide certificates of analysis (CoA) to verify quality. Bulk purchases may offer cost advantages, with prices commonly ranging from $50 to $100 per kilogram. Consider suppliers with ISO certification and inquire about packaging options, such as moisture-resistant containers, to ensure product integrity during transit.
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