Overview
4-Chloroindole is a chlorinated derivative of indole, a heterocyclic aromatic compound. It serves as a versatile intermediate in organic synthesis, particularly in the pharmaceutical and agrochemical industries. The compound is characterized by the presence of a chlorine atom at the 4-position of the indole ring, which enhances its reactivity and utility in various chemical reactions. 4-Chloroindole is primarily used in research and industrial applications due to its role in synthesizing more complex molecules. Its stability and reactivity make it a valuable building block for developing active pharmaceutical ingredients (APIs) and specialty chemicals.
Physical and Chemical Properties
4-Chloroindole appears as a white to pale yellow crystalline powder with a molecular weight of 151.59 g/mol. It has a melting point of approximately 90-95°C and is soluble in common organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO), though it is only slightly soluble in water. The chlorine substitution at the 4-position of the indole ring significantly influences its chemical behavior, making it more reactive toward electrophilic and nucleophilic reactions. This property is exploited in synthetic chemistry to create derivatives with specific functional groups for targeted applications.
Main Applications
4-Chloroindole is widely used as an intermediate in the synthesis of pharmaceuticals, including potential drugs for neurological and anti-inflammatory applications. Its reactivity allows for the introduction of additional functional groups, enabling the development of novel compounds with desired biological activities. In agrochemical research, 4-chloroindole is employed to create pesticides and herbicides. Its structural features contribute to the design of molecules that interact with specific biological targets in pests or weeds, improving efficacy and selectivity.
Safety and Storage
4-Chloroindole should be handled with caution due to its potential health hazards. Direct contact with skin or eyes may cause irritation, and inhalation of dust or vapors should be avoided. Proper personal protective equipment (PPE), such as gloves and safety goggles, is recommended when working with this compound. Storage conditions are critical to maintaining the stability of 4-chloroindole. It should be kept in a cool, dry place, away from light and moisture, preferably in a tightly sealed container. Exposure to incompatible substances, such as strong oxidizing agents, should be avoided to prevent hazardous reactions.
B2B Procurement Guide
When procuring 4-chloroindole, B2B buyers should prioritize purity (typically 97-99%) and supplier reliability. Certificates of Analysis (CoA) should be requested to verify the compound's quality and consistency. Bulk purchases may offer cost advantages, but storage capacity and shelf-life considerations should be evaluated. Suppliers specializing in fine chemicals and pharmaceutical intermediates are preferred sources. Buyers should also inquire about packaging options (e.g., glass bottles, aluminum foil bags) to ensure product integrity during transportation and storage.
Related Manufacturers
- 主营：磷钼酸、艾拉莫德中间体、甲基丙二酸、6-二羟基吲哚、β-丙氨酸甲酯盐酸盐、聚二羟基吲哚、7-去氢胆固醇、2-辛基十二醇、D-荧光素钾盐、BIS-TRIS、光引发剂、苯芴醇、溴芬酸钠中间体、樟脑醌、钼酸钾、丝素蛋白、盐酸胍、甘氨胆酸钠盐、半叶素、胆固醇、蛋白酶K、光引发剂LAP、甲基丙烯酸氧杂环丁烷
- 主营：橡胶油、白芷油、艾叶油、7782-92-5、pbtcaona4、2905-60-4、5989-81-1、1305-62-0、1192-62-7、9005-32-7、7775-27-1、8050-09-7、1739-84-0、7786-30-3、6920-22-5、1897-52-5、7727-21-1、二甲基、桉树醇、重质苯、活性炭、安息油、正辛烷、黄糊精、三辛胺
- 主营：硼酸酐、阻聚剂、己二酸、6-氯嘌呤、氯化锂、发泡剂、乙二醇、醋酸铜、硅酸钠、正癸醇、新癸酸、环烷油、腰果酚、十二醇、酒石酸、碳酸锂、三甘醇、油菜酸、二甘醇、碳酸钾、甲酸钠、硅酸镁、棕榈油、微晶石蜡、磷酸一铵
- 主营：石油醚、四氢噻吩、顺酐、苯酐
- 主营：正癸酸、樊多B醛、聚乙二醇甲醚甲基丙烯酸酯、5-三甲基己醛、山梨醇缩水甘油醚、聚苯胺、磷脂酸铵盐、谷胱甘肽、二氧化钒、三羟甲基氨基甲烷盐酸盐、3二羟基萘、二苯酮、庚酰氯、菲尼酮、茶香醇、苹果酸、菠萝醚
- 主营：胆酸、半叶素、缩合剂、二羟基吲哚、L-丙交酯、生物缓冲液、表面活性剂、硅烷偶联剂、光电材料中间体、精细化工
- 主营：5氰基吲哚、阿昔洛韦侧链、化工原料
- 主营：植物醇、植物提取物、磷钼酸、8-二氨基萘、4-萘二甲酸、8-氨基喹哪啶、聚二羟基吲哚、2-巯基噻唑啉、6-二羟基吲哚氢、4-辛氧基二苯碘六氟、DL-樟脑醌、4-羟乙基哌嗪乙磺酸、5-甲基 N-乙烯基、L-谷氨酸-5-叔丁、聚季铵盐-55、石胆酸、乙烯基膦酸、劳伦酸、二水合钼酸钠、麦角硫因、羟乙基磺酸、钼酸、甲基丙烯酸氧杂环丁烷、三羟甲基氨基甲烷盐酸、腺苷
- 主营：水解角蛋白、石胆酸钠盐、熊去氧胆酸钠盐、6-二羟基吲哚、二羟基吲哚啉氢溴酸、7-去氢胆固醇、2-辛基十二醇、2-巯基噻唑啉、2-巯基苯并咪唑、苯基周位酸(8-苯胺、L-丙交酯、1-氨基环丙烷羧酸、4-联苯甲醇丙烯酸酯、4-羟乙烯基氧基二苯、D(+)-丙交酯、半叶素、乙烯利、环丙磺酰胺、苄氧基胺盐酸盐、咪鲜胺、可比落、乙交酯
- 主营：四乙酰核糖、双乙酰阿昔洛韦、三乙酰更昔洛韦、N4-乙酰胞嘧啶、胞苷、腺嘌呤、吡唑胺、对羟基苯乙酮、半胱胺盐酸盐、钼酸钠、碳酸锆
- 主营：硫磺粉末
- 主营：杂环化合物、丙烯酸系列
- 主营：正辛胺、柠檬酸、尿嘧啶、15397-15-6、119736-16-2、4-嘧啶酮、923289-21-8、152628-02-9、2346620-55-9、抗皱素、绿原酸、异丁基、三辛胺、双醚芴、姜黄素、角鲨烯、精磺胺、蒜氨酸、九甘醇、氟苯基、苯甲酰胺、比卡鲁胺、四氢嘧啶、氨基二环、麦角硫因
- 主营：苯甲醛、酰亚胺、苯磺酸、cas-50-63-5、异丙基、氨基丙基、试剂医药、化学醋酸、化学试剂、甲基硅基、盐酸羟胺、苯并三唑、苄基丙酮、试剂化工、丙烯酰氯、甲基乙炔、氮杂苯并、二叔丁酯、磷酸二苯酯、化学碳酸钾、二酸二乙酯、酸二异丙酯、二咪唑羰基、中间体化工、医药中间体
- 主营：亚索化学试剂、化学试剂、生物试剂、检测试剂、化学色谱纯试剂、光谱纯试剂、分析纯AR试剂、优级纯GR试剂、基准试剂、高纯电子级试剂、标准化学试剂、滴定分析试剂、实验室试剂、通用试剂